Defective oocytes: a new subgroup of unexplained infertility
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Abstract
ObjectiveTo define a new category of unexplained infertility and its potential treatment.DesignNormal infertile couples underwent prospectively, cross-fertilization attempts in which the wife's oocytes were inseminated by the husband and donor semen. After recurrent failure of fertilization, cross insemination of donor oocytes was attempted with the husband sperm.SettingIn vitro fertilization unit at a teaching hospital.PatientsThree couples who were diagnosed as suffering of unexplained infertility and treated by in vitro fertilization (IVF).ResultsThe female partner of these couples produced morphologically normal oocytes that were demonstrated to be functionally defective and failed to fertilize in vitro with both husband and donor sperm. Donated oocytes inseminated by the husband's sperm were fertilized in all patients, demonstrating the normal fertilizing ability of the husbands' semen. One patient conceived and delivered after an oocyte donation.ConclusionsConclusive diagnosis of defective oocytes as a cause of infertility may be made only after IVF and oocyte donation.
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Cites (4)
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Cited by (3)
- The results of in vitro fertilization-embryo transfer in couples with unexplained infertility failing to conceive with superovulation and intrauterine insemination 1995
- Unexplained infertility categorization based on female laparoscopy and total motile sperm count, and its impact on cumulative live‐births after one in‐vitro fertilization cycle. A retrospective cohort study involving 721 cycles 2021
- Subzonal insertion, a possible treatment for ?defective oocytes? 1993
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Cited by (3)
- Unexplained infertility categorization based on female laparoscopy and total motile sperm count, and its impact on cumulative live‐births after one in‐vitro fertilization cycle. A retrospective cohort study involving 721 cycles 2021
- The results of in vitro fertilization-embryo transfer in couples with unexplained infertility failing to conceive with superovulation and intrauterine insemination 1995
- Subzonal insertion, a possible treatment for ?defective oocytes? 1993
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