Diagnosis of luteinized unruptured follicle (LUF) syndrome by ultrasound
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This paper investigated the use of ultrasound for diagnosing luteinized unruptured follicle (LUF) syndrome.
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Abstract
To evaluate the role of ultrasound in diagnosing luteinized unruptured follicle (LUF), 37 women with unexplained infertility were examined for two to three menstrual cycles. Laparoscopy or laparotomy was performed on days 16 to 18 of the third study cycle in 25 patients. The LUF syndrome was suspected at ultrasound examination in 57 of 100 cycles observed. In the remaining 43 cycles, follicular collapse was observed in 33, and 10 were diagnosed as anovulatory. At laparoscopy or laparotomy on 25 patients, 18 of the 21 patients diagnosed as having LUF by ultrasound had a corpus luteum without a stigma. The other three cases diagnosed as LUF by ultrasound had ovulation stigmata. Additional findings in the 25 patients who underwent laparotomy or laparoscopy were endometriosis in 7 (5 of whom had LUF as well), ovulation in 5, bilateral hydrosalpinx in 1, and inability to visualize the ovaries because of adhesions in 1. The LUF syndrome was not a consistent change in the ovulatory pattern of most of the patients. It occurred by ultrasound diagnosis in three consecutive cycles in only 34% of patients.
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Cited by (14)
- Potential Etiologies of Unexplained Infertility in Females 2015
- Nonsteroidal Anti-Inflammatory Drugs and Reversible Female Infertility 2002
- Role of color Doppler ultrasonography in the diagnosis of endometriotic cyst. 2000
- Pathophysiology of Endometriosis-Associated Infertility 1999
- Biases in the endometriosis literature 1998
- Increased Incidence and Recurrence of Recent Corpus Luteum Without Ovulation Stigma (Luteinized Unruptured Follicle Syndrome?) in Baboons With Endometriosis 1996
- Luteinized unruptured follicle in the early stages of endometriosis as a cause of unexplained infertility 1992
- The impact of previous danazol treatment on circulating hormone levels, follicular development and oocyte maturity in minimal-mild endometriosis 1991
- Endometriosis and infertility 1991
- Endometriosis and infertility 1990
- Minimal/mild endometriosis and infertility. A review 1989
- Pelvic Endometriosis 1987
- Mild endometriosis and ovulatory dysfunction: effect of danazol treatment on success of ovulation induction 1986
- Follicle growth patterns and endocrinological abnormalities in infertile women with minor degrees of endometriosis 1986
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- europepmc
- last seen: 2026-09-07T06:12:11.729357+00:00
- openalex
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- pubmed
- last seen: 2026-05-13T22:09:55.985569+00:00
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