The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation

H B Zeyneloglu, Hulusi Bülent Zeyneloğlu, L M Senturk, Levent M. Şentürk, Seli E, Emre Seli, E Seli, E Oral, Ebru Oral, Oral E, David L. Olive, Olive DL, D L Olive, Aydın Arıcı, Arici A, A Arici
Human Reproduction · 1998 · vol. 13(5) , pp. 1194–1199 · doi:10.1093/humrep/13.5.1194 · PMID:9647546 · W1985335819
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Women with intraperitoneal adhesions had elevated peritoneal fluid MCP-1 levels, but this correlation was not observed in patients with endometriosis.

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Abstract

Abdomino-pelvic adhesions arise from infection, endometriosis, or peritoneal injury during surgery, and represent a significant source of morbidity in women of reproductive age. Monocyte chemotactic protein-1 (MCP-1) plays a role in the chemotaxis of mononuclear cells and fibroblasts in a murine wound repair model. To evaluate the role of MCP-1 in intraperitoneal adhesion formation, we investigated peritoneal fluid MCP-1 levels of women undergoing laparoscopy. Patients without endometriosis were divided into two groups: normal fertile women undergoing bilateral tubal ligation without intraperitoneal adhesions (n=14) and women with pelvic adhesions (n=8). Patients with endometriosis were arranged into two groups: women with (n=17) and without (n=17) adhesions. Peritoneal fluid MCP-1 levels were quantified using an enzyme-linked immunosorbent assay (ELISA). Peritoneal biopsy samples were immunostained for the detection of MCP-1 protein and macrophages, and were also processed for the presence of MCP-1 mRNA expression. Among women without endometriosis, the median peritoneal fluid MCP-1 level was 144 pg/ml (range 54-261) in women without adhesions and was 336 pg/ml (range 130-2494) in women with adhesions (P=0.01). There was a significant correlation between adhesion scores and MCP-1 levels (r=0.50; P=0.018). Among women with endometriosis, peritoneal fluid MCP-1 levels significantly correlated with the stage of the disease. The presence or absence of adhesions did not significantly affect the peritoneal fluid MCP-1 levels in this group of women. In summary, we have found that women with adhesions have elevated peritoneal fluid MCP-1 levels. However, we were not able to show an incremental effect of adhesions on peritoneal fluid MCP-1 levels of patients with endometriosis. Thus, we conclude that factors besides the intraperitoneal adhesions contribute to the elevated peritoneal fluid MCP-1 levels in patients with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Chemokine CCL2 Peritoneal Diseases Adult Adult Animals Animals Ascitic Fluid Ascitic Fluid Ascitic Fluid Base Sequence Base Sequence Case-Control Studies Case-Control Studies Chemokine CCL2 Chemokine CCL2 Chemokine CCL2 Chemotaxis, Leukocyte Chemotaxis, Leukocyte Chemotaxis, Leukocyte Endometriosis

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