PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with endometriosis

Nick A. Bersinger, Bersinger NA, von Roten S, Stéphanie von Roten, Wunder DM, Dorothea M Wunder, Dorothea Wunder, Luigi Raio, Raio L, Ekkehard Dreher, E. Dreher, Dreher E, Michael D. Mueller
American journal of obstetrics and gynecology · 2006 · vol. 195(1) , pp. 103–108 · doi:10.1016/j.ajog.2005.12.010 · PMID:16635455 · W2085124613
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This study found elevated levels of PAPP-A, osteoprotegerin, interleukin-8, and RANTES in the peritoneal fluid of women diagnosed with endometriosis.

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Abstract

ObjectiveThe purpose of this study was to evaluate whether pregnancy-associated plasma protein A, glycodelin, osteoprotegerin, and soluble CD163 are possible peritoneal fluid markers for endometriosis and to compare them with the established chemokine markers interleukin-8 and regulated on activation, normal T-cell expressed and secreted.Study designDetermination of the concentrations of interleukin-8, regulated on activation, normal T-cell expressed and secreted, pregnancy-associated plasma protein A, glycodelin, CD163, osteoprotegerin, and progesterone in the peritoneal fluid collected from women undergoing laparoscopy.ResultsFrom a total of 132 women, 77 women were diagnosed with endometriosis, and 55 women were free of the disease and served as control subjects. Pregnancy-associated plasma protein A and osteoprotegerin showed significantly (P < 0.05) elevated peritoneal fluid concentrations as a function of the severity of the disease, together with interleukin-8 and regulated on activation, normal T-cell expressed and secreted (P < .001). Glycodelin and CD163 did not differ between cases and control subjects. Many of these marker concentrations were intercorrelated strongly.ConclusionPregnancy-associated plasma protein A and osteoprotegerin may play a role in the inflammation process of endometriosis, but interleukin-8 and regulated on activation, normal T-cell expressed and secreted are superior peritoneal fluid markers.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Chemokine CCL5 Endometriosis Glycoproteins Interleukin-8 Pregnancy-Associated Plasma Protein-A Receptors, Cytoplasmic and Nuclear Receptors, Tumor Necrosis Factor Adult Ascitic Fluid Chemokine CCL5 Endometriosis Female Glycoproteins Humans Interleukin-8 Osteoprotegerin Pregnancy-Associated Plasma Protein-A Receptors, Cytoplasmic and Nuclear Receptors, Tumor Necrosis Factor

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