NF-κB Decoy Oligonucleotides Suppress RANTES Expression and Monocyte Chemotactic Activity via NF-κB Inactivation in Stromal Cells of Ectopic Endometrium
NF-κB decoy oligonucleotides reduced NF-κB activation, RANTES expression, and monocyte chemotactic activity in IL-1β-induced ectopic endometrial stromal cells.
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The paper studied whether NF-κB decoy oligonucleotides could inhibit NF-κB activation, RANTES expression, and monocyte chemotactic activity in vitro in IL-1β-stimulated ectopic endometrial stromal cells, with comparisons to normal endometrial stromal cells. Using electrophoretic mobility shift assays for NF-κB activation, ELISA for RANTES secretion, and Boyden chambers for monocyte chemotaxis, it found that IL-1β induced higher, time-dependent RANTES expression in ectopic stromal cells, and that RANTES accounted for 68% of monocyte chemotactic activity in ectopic-conditioned media. Transfection with NF-κB decoy ODNs markedly decreased NF-κB activation, RANTES expression, and monocyte chemotactic activity in the IL-1β-induced ectopic stromal cells. This paper is centrally about endometriosis — it focuses on modulating NF-κB–dependent RANTES-driven inflammatory chemotaxis in stromal cells of ectopic endometrium in endometriosis.
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Cited by (10)
- Neurotrophins and Their Receptors, Novel Therapeutic Targets for Pelvic Pain in Endometriosis, Are Coordinately Regulated by IL-1β via the JNK Signaling Pathway 2023
- An Update on the Multifaceted Role of NF-kappaB in Endometriosis 2022
- Endometriosis: A Disease with Few Direct Treatment Options 2022
- Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies† 2021
- Endometriotic inflammatory microenvironment induced by macrophages can be targeted by niclosamide† 2018
- Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics 2016
- The role of SRC1 and SRC2 in steroid-induced SDF1 expression in normal and ectopic endometrium 2014
- Chemokines in the pathogenesis of endometriosis and infertility 2013
- Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis 2010
- Involvement of the nuclear factor-kB pathway in the pathogenesis of endometriosis 2010
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