Thiazolidinedione Inhibition of Peritoneal Inflammation

Daniela Hornung, Victor A Chao, Jean-Louis Vigne, Jean‐Louis Vigne, Diethelm Wallwiener, D. Wallwiener, Robert N Taylor
Gynecologic and obstetric investigation · 2003 · vol. 55(1) , pp. 20–24 · doi:10.1159/000068952 · PMID:12624547 · W2035351560
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Thiazolidinediones like ciglitazone inhibited macrophage infiltration and pro-inflammatory cytokine secretion in a murine model of peritoneal inflammation.

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Abstract

Chemoattraction of macrophages into the peritoneal cavity is one of the important characteristics in patients with endometriosis. An inflammatory response is postulated to be responsible for infertility and pelvic pain associated with this syndrome. The present in vivo studies were designed to test if thiazolidinediones (TZDs), activators of peroxisome proliferator activated receptor gamma, could inhibit monocyte chemotaxis in a murine model. TZDs were first used as orally bioavailable insulin-sensitizing agents. They are currently under investigation in the treatment of inflammatory diseases, including arthritis or colitis. Intraperitoneal injection of thioglycollate was used to elicit high numbers of activated peritoneal macrophages in female mice. Concomitant peritoneal injection of ciglitazone, a member of the TZD family, significantly reduced the number of macrophages. When cultured and stimulated by tumor necrosis factor alpha, these peritoneal macrophages also secreted less RANTES and less IL-1beta protein. This animal model suggests that treatment of endometriosis patients with TZDs may diminish symptoms associated with intraperitoneal inflammation.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Peroxisome Proliferators Thiazoles Thiazolidinediones Animals Chemokine CCL5 Chemokine CCL5 Disease Models, Animal Endometriosis Endometriosis Female Interleukin-1 Interleukin-1 Leukocyte Count Macrophages, Peritoneal Macrophages, Peritoneal Mice Mice, Inbred C57BL Peritonitis Peritonitis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (25)

Cited by (23)

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