PPAR–gamma: a dagger in endometriosis

Amberkar Mv
In: Australasian medical journal · 2010 · pp. 814–820 · doi:10.4066/amj.2010.261 · W1983359036
article OA: diamond CC0 ⤵ 2 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review highlights how PPAR-gamma agonists, commonly used for diabetes, may suppress endometriosis lesions by inhibiting RANTES-induced monocyte migration.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This short editorial/mini-review addresses PPAR-γ in the context of endometriosis, discussing how PPAR-γ relates to disease mechanisms and its potential relevance as a therapeutic target. It reviews prior knowledge rather than presenting new primary data, and it does not describe original study methods or include patient cohorts. The main caveat is that, as an editorial/review format, its conclusions depend on the existing literature and are not accompanied by systematic, quantitative synthesis or new experimental results. This paper is centrally about endometriosis — specifically the role of PPAR-γ in endometriosis pathophysiology and treatment implications.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a debilitating gynecological disorder with an enigmatic pathogenesis. Current treatment strategy mainly involves surgery and medications, which provide only temporary relief. Endometriosis is associated with an abnormal inflammatory response, one of the recent pathogenesis is RANTES (regulated upon activation normal Tcell expressed and secreted) in endometriotic stromal cells, which is responsible for 70% of monocyte migration in the peritoneal fluid. This RANTES can be inhibited by the peroxisome proliferator activated receptor system. Thiazolidinediones (PPAR Gamma Agonists) exhibited the ability shown to suppress existing endometriotic lesions without suppressing ovulation. In vivo studies have shown some promising results which could be incorporated in humans. These results have promised new avenues of treatment emerging from older drugs. Since the existing conventional drugs have undesirable side effects, there is always a need for highly efficacious and better tolerated drugs acting through novel mechanisms of action. Hence , in this review we have highlighted the usage of a class of drugs commonly used to treat diabetes mellitus, which could also be used to treat endometriosis.
Full text 1,171 characters · extracted from oa-html · click to expand
ISSN 1836-1935. Australasian Medical Journal This editorial explores anatomy's evolving role in medicine.Read mo... Read More This mini review provides an overview of the use of antimalarial ag... Read More This case report highlights the importance of a detailed history, ... Read More Diabetes mellitus is one of the leading causes of morbidity and mor... Read More This study highlights about low social support which found to be a ... Read More In Australia, renal transplant patients of the Northern Territory (... Read More A retrospective analysis identifies and assess the risk of developi... Read More - 1 - 2 - 3 - 4 - 5 - 6 - 7 The AMJ is an open access Medical Journal. We focus on health innovation and debate serving a global community. A modest publication charge is levied to cover costs. To submit papers, serve as a reviewer or to receive email alerts when new editions are published please register. Our papers are published as PDF files. A PDF reader is available on this link. The AMJ is indexed on the following databases: Web of Science, Proquest , National Library of Australia, and DRJI. ResearchGate Impact Factor: 25.96, Google Scholar h5 index

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (58)

Cited by (2)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK