New drugs in development for the treatment of endometriosis

Luigi Fedele; Edgardo Somigliana; Giada Frontino; Laura Benaglia; Paola Vigano; Paola Viganò

doi:10.1517/13543784.17.8.1187

New drugs in development for the treatment of endometriosis

Luigi Fedele, Edgardo Somigliana, Giada Frontino, Laura Benaglia, Paola Vigano, Paola Viganò

Expert opinion on investigational drugs · 2008 · vol. 17(8) , pp. 1187–1202 · doi:10.1517/13543784.17.8.1187 · PMID:18616415 · W2048751813

review OA: closed CC0 ⤵ 20 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review examines new endometriosis drug candidates supported by in vivo and human research, highlighting promising anti-inflammatory agents and refined uses for existing therapies.

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Abstract

Endometriosis is a common and enigmatic disease causing pelvic pain and infertility. Current treatment is mainly based on the use of surgery and ovarian suppressive agents. There is in particular the need for new therapeutic options able to allow a normal menstrual cycle to occur and also consent pregnancy. In the present review, we aimed to give a concise and practical overview in order to allow the clinician to clearly understand the level of development of these drugs. We have presented only treatments supported by in vivo researches with a special attention to studies in humans. Results show appealing new possibilities are emerging from agents counteracting the endometriosis-associated inflammation. Recent data also suggests that there is still the opportunity to refine the use of already available agents.

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Condition tags

endometriosisinfertility

MeSH descriptors

Drug Design Endometriosis Angiogenesis Inhibitors Angiogenesis Inhibitors Angiogenesis Inhibitors Angiogenesis Inhibitors Animals Anti-Inflammatory Agents Anti-Inflammatory Agents Anti-Inflammatory Agents Anti-Inflammatory Agents Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Endometriosis Endometriosis Endometriosis Endometriosis Female

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References (100)

Cited by (20)

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