Investigational developments for the treatment of progesterone-dependent diseases

Carsten Möller, Jens Hoffmann, Thomas A Kirkland, Wolfgang Schwede
Expert opinion on investigational drugs · 2008 · vol. 17(4) , pp. 469–479 · doi:10.1517/13543784.17.4.469 · PMID:18363513 · W2159309145
review OA: closed CC0 ⤵ 4 in-corpus citations
View on OpenAlex View on PubMed View at publisher

Abstract

BACKGROUND: Clinical evidence has shown that conditions such as uterine fibroids, endometriosis and breast cancer are progesterone-dependent diseases. Therefore, progesterone receptor (PR) antagonists and selective PR modulators (SPRMs) are under development for the treatment of these conditions. However, the first PR antagonists that became available exhibit insufficient selectivity or tolerability for the chronic administration required to treat these conditions. Despite initial setbacks, development of second-generation PR antagonists with better selectivity continues forward. OBJECTIVE: In this review we would like to summarise prospects for using PR antagonists for the treatment of uterine fibroids, endometriosis and breast cancer, and to give an overview of the development of new steroidal and non-steroidal PR antagonists. METHOD: Available preclinical and clinical data and publications have been reviewed with the focus on scientific background and use in the three mentioned indications. RESULTS/CONCLUSION: Preclinical and clinical evidence demonstrated that PR antagonists and SPRMs are effective for the treatment of progesterone-dependent diseases. Future development will demonstrate if they can become important drugs.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Antineoplastic Agents Drugs, Investigational Hormone Antagonists Progesterone Receptors, Progesterone Animals Antineoplastic Agents Antineoplastic Agents Breast Neoplasms Breast Neoplasms Breast Neoplasms Cell Proliferation Cell Proliferation Drug Partial Agonism Drugs, Investigational Drugs, Investigational Endometriosis Endometriosis Endometriosis Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (74)

Cited by (4)

Source provenance

europepmc
last seen: 2026-06-23T06:15:44.889181+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:14:36.758325+00:00
License: CC0 · commercial use OK