The mTOR/AKT Inhibitor Temsirolimus Prevents Deep Infiltrating Endometriosis in Mice

Mahaut Leconte, Carole Nicco, Charlotte Ngô, Christiane Chéreau, Sandrine Chouzenoux, Wioleta Marut, Jean Guibourdenche, Sylviane Arkwright, S Arkwright, Bernard Weill, Charles Chapron, B. Dousset, Bertrand Dousset, Frédéric Batteux
The American journal of pathology · 2011 · vol. 179(2) , pp. 880–889 · doi:10.1016/j.ajpath.2011.04.020 · PMID:21718677 · PMC3157265 · W1973747294
article OA: bronze CC0 ⤵ 79 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Temsirolimus, an mTOR/AKT inhibitor, reduced the size and number of deep infiltrating endometriosis lesions in a mouse model.

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Endometriosis Sirolimus Adult Animals Biopsy Cell Proliferation Disease Models, Animal Endometriosis Endometrium Endometrium Female Humans Mice Mice, Nude Middle Aged Oxidative Stress Phenotype Protein Kinase Inhibitors Protein Kinase Inhibitors Reactive Oxygen Species

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