Ribosome Biogenesis Serves as a Therapeutic Target for Treating Endometriosis and the Associated Complications

Cherry Yin-Yi Chang, Cherry Yin‐Yi Chang, An-Jen Chiang, An‐Jen Chiang, Man-Ju Yan, Ming-Tsung Lai, Ming‐Tsung Lai, Yun-Yi Su, Hsin-Yi Huang, Hsin‐Yi Huang, Chan-Yu Chang, Yahui Li, Ya-Hui Li, Pei-Fen Li, Chih‐Mei Chen, Chih-Mei Chen, Tritium Hwang, Chloe Hogg, Erin Greaves, Jim Jinn‐Chyuan Sheu, Jim Jinn-Chyuan Sheu
Biomedicines · 2022 · vol. 10(1) , pp. 185 · doi:10.3390/biomedicines10010185 · PMID:35052864 · PMC8774031 · W4206744723
article OA: gold CC0
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that inhibiting ribosome biogenesis with mTOR or RNA polymerase I inhibitors significantly reduced endometriosis lesions and inflammation in a mouse model.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Ribosome biogenesis is a cellular process critical for protein homeostasis during cell growth and multiplication. Our previous study confirmed up-regulation of ribosome biogenesis during endometriosis progression and malignant transition, thus anti-ribosome biogenesis may be effective for treating endometriosis and the associated complications. A mouse model with human endometriosis features was established and treated with three different drugs that can block ribosome biogenesis, including inhibitors against mTOR/PI3K (GSK2126458) and RNA polymerase I (CX5461 and BMH21). The average lesion numbers and disease frequencies were significantly reduced in treated mice as compared to controls treated with vehicle. Flow cytometry analyses confirmed the reduction of small peritoneal macrophage and neutrophil populations with increased large versus small macrophage ratios, suggesting inflammation suppression by drug treatments. Lesions in treated mice also showed lower nerve fiber density which can support the finding of pain-relief by behavioral studies. Our study therefore suggested ribosome biogenesis as a potential therapeutic target for treating endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (64)

Source provenance

europepmc
last seen: 2026-06-12T06:13:51.797165+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:24:03.506079+00:00
License: CC0 · commercial use OK