Mechanisms of pain in endometriosis

Matteo Morotti, Katy Vincent, Becker CM, Christian M Becker
European journal of obstetrics, gynecology, and reproductive biology · 2016 · vol. 209 , pp. 8–13 · doi:10.1016/j.ejogrb.2016.07.497 · PMID:27522645 · W2491747125
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper explores the complex mechanisms underlying pain in endometriosis, focusing on the roles of inflammation, nerve growth, and cellular signaling.

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Abstract

Pain is the central symptom in endometriosis and often persists despite treatment of the disease. Multiple mechanisms underlie endometriosis-associated pain including nociception, inflammation, and alterations in peripheral and central nervous system pain processing. As also occuring in other chronic conditions, pain in endometriosis is often associated with psychological distress and fatigue, both of which may amplify pain. It is hoped that in the future methods of phenotyping women on the basis of the underlying pain mechanisms will be developed, likely combining a critical evaluation of clinical symptoms and signs with laboratory and imaging tests. Optimal pain relief for an individual is more likely if her specific contributory pain mechanisms are identified and appropriately addressed. Such methods may also improve the selection of patients for clinical trials, potentially increasing the probability of identifying novel treatments for the many women with endometriosis for whom acceptable analgesia is not achieved.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Pelvic Pain Pelvic Pain Endometriosis Endometriosis Female Humans Pain Management Pelvic Pain Stress, Psychological Stress, Psychological

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (54)

Cited by (50)

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License: CC0 · commercial use OK