TRPV1 Expression on Peritoneal Endometriosis Foci is Associated With Chronic Pelvic Pain

Marcelo Gondim Rocha, Júlio César Rosa e Silva, Alfredo Ribeiro da Silva, Francisco José Cândido dos Reis, Francisco José Candido Dos Reis, Antônio Alberto Nogueira, Antonio Alberto Nogueira, Omero Benedicto Poli-Neto, Omero Benedicto Poli‐Neto
Reproductive sciences (Thousand Oaks, Calif.) · 2010 · vol. 18(6) , pp. 511–515 · doi:10.1177/1933719110391279 · PMID:21160085 · W2077063716
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TRPV1 expression in peritoneal endometriosis foci was more frequent in women with chronic pelvic pain compared to those without.

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This case-control study investigated whether the capsaicin receptor TRPV1 is differentially expressed on peritoneal endometriosis foci in 49 women undergoing laparoscopy, comparing 28 with chronic pelvic pain (CPP) to 21 without CPP. Peritoneal specimens from the rectouterine excavation were obtained and analyzed by immunohistochemistry for TRPV1, and the authors reported that TRPV1 immunoreactivity was more frequent in endometriosis foci from women with CPP than those without CPP (53.6% vs 28.6%, P = .04). The association with TRPV1 did not correlate with CPP duration, pain intensity, or endometriosis stage, and the authors acknowledge that the study is observational and limited to peritoneal lesions sampled at laparoscopy. This paper is centrally about endometriosis — it links TRPV1 expression on peritoneal endometriosis foci to chronic pelvic pain.

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Abstract

Objective To investigate the expression of capsaicin receptor (transient receptor potential vanilloid type 1 [TRPV1]) in the peritoneal endometriosis foci of women with and without chronic pelvic pain (CPP).

Methods

A case−control study was conducted on 49 women with endometriosis who underwent laparoscopy, 28 of whom had CPP and 21 without CPP. Samples from peritoneum of the rectouterine excavation (2 cm2) were obtained by laparoscopy, fixed in 4% formaldehyde, and underwent immunohistochemistry analysis using rabbit anti-TRPV1 (1:400) polyclonal antibody.

Results

Image analysis revealed that the immunoreactivity for TRPV1 was more frequent in specimens (endometriosis foci) from women with CPP (n = 15 of 28, 53.6%), compared to samples from the endometriosis foci of women without CPP (n = 6 of 21, 28.6%; P =.04). There was no correlation with duration, intensity of pain, or stage of the disease (endometriosis).

Discussion

The present study shows that TRPV1 expression in peritoneal endometriosis foci is related to CPP in women. However, this association is not related to the endometriosis stage. In view of the immunoreactivity for TRPV1 observed here, we believe that some endometriotic lesions may provide a scenario for TRPV1 to be tonically active and this activity may contribute to the underlying pathology of CPP. Similar content being viewed by others

References

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Pelvic Pain Peritoneum TRPV Cation Channels Adult Case-Control Studies Chronic Disease Endometriosis Endometriosis Female Humans Laparoscopy Pelvic Pain Pelvic Pain Pelvic Pain Peritoneum Severity of Illness Index TRPV Cation Channels

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