Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis

T Yagyu, Yagyu T, Tatsuo Yagyu, Tsuji Y, Y Tsuji, Yasushi Tsuji, Shoji Haruta, Haruta S, S Haruta, Kitanaka T, Takashi Kitanaka, T Kitanaka, Y Yamada, Yamada Y, Yasuhiro Yamada, Ryuji Kawaguchi, R Kawaguchi, Kawaguchi R, Kanayama S, S Kanayama, Seiji Kanayama, Y Tanase, Yasuhito Tanase, Tanase Y, Noriyuki Kurita, N Kurita, Kurita N, Hiroshi Kobayashi, H Kobayashi, Kobayashi H
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2006 · vol. 16(4) , pp. 1545–1551 · doi:10.1111/j.1525-1438.2006.00625.x · PMID:16884363 · W2045779236
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This study investigated the activation of the mammalian target of rapamycin (mTOR) pathway in ovarian endometriosis in postmenopausal women.

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Abstract

The purpose of this study was to determine whether Akt and mammalian target of rapamycin (mTOR), downstream targets of phosphatidylinositol 3-kinase, are activated in endometriosis and ovarian cancer specimens. We measured total and phosphorylated levels of Akt and mTOR from 17 frozen ovarian cancers and 15 benign endometriosis specimens (nine from premenopausal women and six from postmenopausal women) by quantitation of signals from western blots using antibodies against these proteins. Elevated phospho-Akt was detected in ovarian cancer versus endometriosis specimens from premenopausal women and endometriosis specimens from postmenopausal women (2.3 +/- 0.45 versus 0.10 +/- 0.06 and 0.17 +/- 0.11; P < 0.05) when the western blot signal of activated kinase was normalized to total kinase levels. Elevated phospho-mTOR was detected in ovarian cancer and postmenopausal endometriosis versus premenopausal endometriosis (0.52 +/- 0.19 and 0.46 +/- 0.29 versus 0.13 +/- 0.08; P < 0.05). Expression of total kinases (normalized to beta-actin) was higher in carcinoma versus endometriosis specimens. Elevation of the active mTOR was specifically detected in postmenopausal endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Neoplasms Postmenopause Protein Kinases Adult Aged Aged, 80 and over Blotting, Western Endometriosis Endometriosis Female Humans Middle Aged Ovarian Neoplasms Ovarian Neoplasms Phosphatidylinositol 3-Kinases Phosphatidylinositol 3-Kinases Phosphorylation Postmenopause Protein Kinases

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