Malignant transformation of endometriosis and genetic alterations of K‐ras and microsatellite instability
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K-ras mutation and microsatellite instability were detected in ovarian endometrioid carcinoma tissue but not in adjacent normal or atypical endometriosis, suggesting their association with malignant transformation.
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Abstract
OBJECTIVES: To clarify the role of specific genetic alterations in the multi-step process of malignant transformation of endometriosis. METHODS: In cases of ovarian endometrioid carcinoma, we separated regions of normal endometriosis, atypical endometriosis and ovarian endometrioid carcinoma by laser microdissection, and examined K-ras mutation and microsatellite instability in each separated tissue sample. RESULTS: We detected K-ras mutation and microsatellite instability in endometrioid carcinoma tissue, but not in normal or atypical endometriosis bordering the cancerous region. CONCLUSIONS: The present findings suggest that K-ras mutation and microsatellite instability are associated with malignant transformation from atypical endometriosis to ovarian endometrioid carcinoma.
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- A Lifelong Impact on Endometriosis: Pathophysiology and Pharmacological Treatment 2023
- Genetics and genomics of endometriosis☆ 2023
- Endometriosis Stem Cells as a Possible Main Target for Carcinogenesis of Endometriosis-Associated Ovarian Cancer (EAOC) 2022
- Endometriosis and its global impact on a woman’s body 2022
- Malignant transformation of abdominal wall endometriosis: A systematic review of the epidemiology, diagnosis, treatment, and outcomes 2021
- Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology 2019
- Genetics and Genomics of Endometriosis 2018
- Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis 2018
- Differential expression of mTOR components in endometriosis and ovarian cancer: Effects of rapalogues and dual kinase inhibitors on mTORC1 and mTORC2 stoichiometry 2018
- Affinity-purified DNA-based mutation profiles of endometriosis-related ovarian neoplasms in Japanese patients 2018
- Ovarian Carcinoma Associated with Endometriosis 2018
- Endometriosis — insights into a multifaceted entity 2018
- New knowledge and insights about the malignant transformation of endometriosis 2017
- Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review) 2014
- Fibroblast Growth Factor Receptor 2 Expression May Be Involved In Transformation of Ovarian Endometrioma to Clear Cell Carcinoma of the Ovary 2013
- Les cancers de l’ovaire associés à l’endométriose : physiopathologie et conséquences sur la pratique clinique 2013
- A polymorphism in a let‐7 microRNA binding site of KRAS in women with endometriosis 2012
- Involvement of pelvic inflammation–related mismatch repair abnormalities and microsatellite instability in the malignant transformation of ovarian endometriosis 2012
- The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis 2012
- Epigenetic inactivation of hMLH1 in the malignant transformation of ovarian endometriosis 2011
- Pathophysiological factors and genetic association in endometriosis 2011
- Oncogenic events associated with endometrial and ovarian cancers are rare in endometriosis 2011
- Research Highlights: Highlights from the latest articles in epigenomics of endometriosis 2011
- Possible involvement of loss of heterozygosity in malignant transformation of ovarian endometriosis 2010
- Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management 2009
- Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (Review) 2009
- Endométriose de cicatrice de la paroi abdominale 2008
- Contents of Endometriotic Cysts, Especially the High Concentration of Free Iron, Are a Possible Cause of Carcinogenesis in the Cysts through the Iron-Induced Persistent Oxidative Stress 2008
- The Role of p53 Mutation in the Carcinomas Arising from Endometriosis 2007
- Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis 2006
- Adie tonic pupil associated to endometriosis 2006
- Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis 2006
- Relationship of Benign Gynecologic Diseases to Subsequent Risk of Ovarian and Uterine Tumors 2005
- Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer 2004
- Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer 2004
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
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- pubmed
- last seen: 2026-05-13T22:12:26.305326+00:00
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