Malignant transformation of endometriosis and genetic alterations of K-ras and microsatellite instability
Other
OA: closed
CC0
⤵ 36 in-corpus citations
AI-generated summary
K-ras mutation and microsatellite instability were detected in ovarian endometrioid carcinoma tissue but not in adjacent normal or atypical endometriosis, suggesting their association with malignant transformation.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
OBJECTIVES: To clarify the role of specific genetic alterations in the multi-step process of malignant transformation of endometriosis.
METHODS: In cases of ovarian endometrioid carcinoma, we separated regions of normal endometriosis, atypical endometriosis and ovarian endometrioid carcinoma by laser microdissection, and examined K-ras mutation and microsatellite instability in each separated tissue sample.
RESULTS: We detected K-ras mutation and microsatellite instability in endometrioid carcinoma tissue, but not in normal or atypical endometriosis bordering the cancerous region.
CONCLUSIONS: The present findings suggest that K-ras mutation and microsatellite instability are associated with malignant transformation from atypical endometriosis to ovarian endometrioid carcinoma.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood (2-hop)
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
References (11)
- Allelotyping of endometriosis with adjacent ovarian carcinoma reveals evidence of a common lineage via openalex
- Cancer risk after a hospital discharge diagnosis of endometriosis via openalex
- ENDOMETRIAL CARCINOMA OF THE OVARY, ARISING IN ENDOMETRIAL TISSUE IN THAT ORGAN via openalex
- Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary via openalex
- Ovarian atypical endometriosis: its close association with malignant epithelial tumours via openalex
- p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer via openalex
- Prevalence and genesis of endometriosis via openalex
- Prevalence of endometriosis in ovarian cancer via openalex
- W2075300416 via openalex
- W2042041038 via openalex
- W2154546296 via openalex
Cited by (36)
- New Evidence About Malignant Transformation of Endometriosis-A Systematic Review 2025
- A Lifelong Impact on Endometriosis: Pathophysiology and Pharmacological Treatment 2023
- Genetics and genomics of endometriosis☆ 2023
- Endometriosis Stem Cells as a Possible Main Target for Carcinogenesis of Endometriosis-Associated Ovarian Cancer (EAOC) 2022
- Endometriosis and its global impact on a woman’s body 2022
- Malignant transformation of abdominal wall endometriosis: A systematic review of the epidemiology, diagnosis, treatment, and outcomes 2021
- Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology 2019
- Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis 2018
- Genetics and Genomics of Endometriosis 2018
- Endometriosis - insights into a multifaceted entity 2018
- Ovarian Carcinoma Associated with Endometriosis 2018
- Differential expression of mTOR components in endometriosis and ovarian cancer: Effects of rapalogues and dual kinase inhibitors on mTORC1 and mTORC2 stoichiometry 2018
- Affinity-purified DNA-based mutation profiles of endometriosis-related ovarian neoplasms in Japanese patients 2018
- New knowledge and insights about the malignant transformation of endometriosis 2017
- Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (review) 2014
- [Endometriosis-associated ovarian cancers: pathogenesis and consequences on daily practice] 2013
- Fibroblast growth factor receptor 2 expression may be involved in transformation of ovarian endometrioma to clear cell carcinoma of the ovary 2013
- The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis 2012
- A polymorphism in a let-7 microRNA binding site of KRAS in women with endometriosis 2012
- Involvement of pelvic inflammation-related mismatch repair abnormalities and microsatellite instability in the malignant transformation of ovarian endometriosis 2012
- Pathogenesis of endometriosis and its relationship to gynecological cancers 2011
- Epigenetic inactivation of hMLH1 in the malignant transformation of ovarian endometriosis 2011
- Oncogenic events associated with endometrial and ovarian cancers are rare in endometriosis 2011
- Pathophysiological factors and genetic association in endometriosis 2011
- Possible involvement of loss of heterozygosity in malignant transformation of ovarian endometriosis 2010
- Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management 2009
- Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (Review) 2009
- Contents of endometriotic cysts, especially the high concentration of free iron, are a possible cause of carcinogenesis in the cysts through the iron-induced persistent oxidative stress 2008
- [Parietal endometriosis in abdominal wall] 2008
- The role of p53 mutation in the carcinomas arising from endometriosis 2007
- Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis 2006
- Adie tonic pupil associated to endometriosis 2006
- Activation of mammalian target of rapamycin in postmenopausal ovarian endometriosis 2006
- Relationship of benign gynecologic diseases to subsequent risk of ovarian and uterine tumors 2005
- Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer 2004
- Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer 2004
Source provenance
- europepmc
- last seen: 2026-10-19T06:17:24.038039+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:02:42.299833+00:00
- unpaywall
- last seen: 2026-10-19T06:34:38.229974+00:00
License: CC0
· commercial use OK