p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer

Tsuyoshi Okuda, Junko Otsuka, Akihiko Sekizawa, Hiroshi Saito, Reiko Makino, Miki Kushima, Antonio Farina, Yuzuru Kuwano, Takashi Okai
Gynecologic oncology · 2003 · vol. 88(3) , pp. 318–325 · doi:10.1016/s0090-8258(02)00149-x · PMID:12648581 · W1986799387
article OA: closed CC0 ⤵ 23 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the impact of p53 mutations and overexpression on patient outcomes in ovarian endometrioid and clear cell cancers, finding a significant prognostic effect only in endometrioid cancer.

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MeSH descriptors

Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Genes, p53 Mutation Ovarian Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adult Aged Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Codon Female Genes, p53 Genes, ras Genes, ras Humans Immunohistochemistry

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License: CC0 · commercial use OK