Relationship between Malignant Transformation of Endometriosis and Genetic Alterations of K-ras and Microsatellite Instability

Satoshi Amemiya, Akihiko Sekizawa, Junko Otsuka, Tsuyoshi Okuda, Tomoko Akahane, Miki Kushima, Tetsuhiko Tachikawa, Hiroshi Saito, Takashi Okai
In: The Showa University Journal of Medical Sciences · 2004 · vol. 16(1) , pp. 47–54 · doi:10.15369/sujms1989.16.47 · W2087972518
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K-ras mutations and microsatellite instability were found in ovarian endometrioid carcinomas, suggesting their involvement in the malignant transformation from atypical endometriosis.

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The study investigated whether specific genetic alterations—K-ras mutations and microsatellite instability—occur during the malignant transformation of endometriosis toward ovarian endometrioid carcinoma. Using laser microdissection, researchers separated tissue from endometriosis, atypical endometriosis, and ovarian endometrioid carcinoma and assessed each region for these genetic changes. K-ras mutation and microsatellite instability were found in endometrioid carcinoma tissue but not in endometriosis or atypical endometriosis bordering the cancerous region. The paper concludes that these alterations may be linked to transformation from atypical endometriosis to ovarian endometrioid carcinoma rather than from endometriosis to atypical endometriosis. This paper is centrally about endometriosis — it examines genetic alterations (K-ras and microsatellite instability) in steps of endometriosis-to-ovarian endometrioid carcinoma malignant transformation.

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Abstract

Several genetic alterations have been associated with the malignant transformation from endometriosis to ovarian cancer. However, the role of each genetic alteration in this multi-step process of tumorigenesis has not been clarified. Regions of endometriosis, atypical endometriosis, and ovarian endometrioid carcinoma were separated by laser microdissection, and examined for the presence of K-ras mutation and microsatellite instability. K-ras mutation and microsatellite instability were detected in endometrioid carcinoma tissue, but not in endometriosis and atypical endometriosis bordering the cancerous region. K-ras mutation and microsatellite instability may be associated with the malignant transformation from atypical endometriosis to ovarian endometrioid carcinoma, but not from endometriosis to atypical endometriosis.
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Keywords

endometriosis, ovarian endometrioid carcinoma, K-ras mutation, microsatellite instability, malignant transformation 2004 Volume 16 Issue 1 Pages 47-54 Details

Abstract

Several genetic alterations have been associated with the malignant transformation from endometriosis to ovarian cancer. However, the role of each genetic alteration in this multi-step process of tumorigenesis has not been clarified. Regions of endometriosis, atypical endometriosis, and ovarian endometrioid carcinoma were separated by laser microdissection, and examined for the presence of K-ras mutation and microsatellite instability. K-ras mutation and microsatellite instability were detected in endometrioid carcinoma tissue, but not in endometriosis and atypical endometriosis bordering the cancerous region. K-ras mutation and microsatellite instability may be associated with the malignant transformation from atypical endometriosis to ovarian endometrioid carcinoma, but not from endometriosis to atypical endometriosis. © The Showa Medical Association Favorites & Alerts Recently viewed articles Successor

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endometriosis

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