The Role of p53 Mutation in the Carcinomas Arising from Endometriosis

Tomoko Akahane, Akihiko Sekizawa, Yuditiya Purwosunu, Masaaki Nagatsuka, Takashi Okai
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2007 · vol. 26(3) , pp. 345–351 · doi:10.1097/pgp.0b013e31802b41a8 · PMID:17581423 · W2040185850
article OA: closed CC0 ⤵ 36 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

p53 mutations were found in endometriosis coexisting with ovarian clear cell carcinoma but not in solitary endometriosis or endometriosis coexisting with endometrioid carcinoma.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

To probe the mechanism of the development of ovarian cancer from endometriosis, which is a multistep process that involves the activation of oncogenes and inactivation of tumor suppressor genes, we evaluated p53 mutations in solitary endometriosis and endometriosis coexisting with ovarian clear cell carcinoma (OCCA) and ovarian endometrioid carcinoma (OEC). We examined 7 cases of solitary ovarian endometriosis, 13 cases of OCCA, and 9 cases of OEC. Cancer tissue specimens that also contained endometriosis without atypia were chosen. Using a laser microdissection system, epithelial cells from the areas of endometriosis were isolated, and DNA was extracted. We amplified exons 5, 6, 7, and 8 of the p53 gene, and direct sequencing was performed. p53 mutation was observed in 4 (30.8%) of 13 specimens of endometriosis coexisting with OCCA, whereas no mutations were detected in solitary endometriosis or endometriosis coexisting with OEC. We thought that some genetic alterations, which induce p53 mutations in endometriosis, may affect malignant transformation of endometriosis into OCCA.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Endometriosis Genes, p53 Ovarian Neoplasms Point Mutation Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adult Aged Carcinoma, Endometrioid Carcinoma, Endometrioid DNA, Neoplasm DNA, Neoplasm DNA, Neoplasm Endometriosis Endometriosis Female Humans Middle Aged

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (23)

Cited by (36)

Source provenance

europepmc
last seen: 2026-06-22T06:15:23.361955+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:14:54.534439+00:00
unpaywall
last seen: 2026-06-22T06:34:40.717867+00:00
License: CC0 · commercial use OK