Expression of apoptosis-related proteins in peritoneal, ovarian and colorectal endometriosis

Charlotte Dufournet, Dufournet C, Catherine Uzan, Uzan C, Fauvet R, R. Fauvet, Raffaèle Fauvet, A. Cortez, Annie Cortez, Cortez A, Jean-Pierre Siffroi, Jean‐Pierre Siffroi, Siffroi JP, Émile Daraï, Emile Daraï, Daraï E
Journal of Reproductive Immunology · 2005 · vol. 70(1-2) , pp. 151–162 · doi:10.1016/j.jri.2005.11.003 · PMID:16378643 · W2121381831
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This study investigated the expression levels of apoptosis-related proteins in peritoneal endometriosis, ovarian endometriomas, and colorectal endometriosis.

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Abstract

Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus. Apoptosis, a physiological process by which multicellular organisms eliminate superfluous cells, is altered in tumor tissue. Here we studied the expression of the apoptosis-related proteins p53, bcl-2, bax, p21 and fas in proliferative (n=9) and secretory (n=9) endometrium, and in peritoneal (n=11), ovarian (n=20) and colorectal (n=20) endometriosis, by qualitative and semi-quantitative immunohistochemical methods using the percentage of positive cells and HSCORE analysis. In endometrium, p53, p21 and fas expression was low, whereas bax and bcl-2 expression was elevated. Using HSCORE analysis, only bcl-2 expression varied during the menstrual cycle (48.9+/-34.2% in the proliferative phase, 11.5+/-24.7% in the secretory phase, p=0.01). Using HSCORE analysis, p53 expression was higher in ovarian endometriosis than in peritoneal (p<0.0001) and colorectal endometriosis (p=0.03). P21 expression was higher in ovarian endometriosis than in peritoneal (p=0.01) and colorectal endometriosis (p=0.01). Bcl-2 expression was lower in ovarian endometriosis than in peritoneal (p=0.0002) and colorectal endometriosis (p<0.0001). Fas expression was higher in peritoneal endometriosis than in ovarian (p=0.02) and colorectal endometriosis (p=0.008). In conclusion, these results confirm the involvement of apoptosis in the pathogenesis of endometriosis. Moreover, expression of apoptosis-related proteins varies according to the location of endometriosis suggesting the involvement of different apoptotic pathways.

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Condition tags

endometriosis

MeSH descriptors

Apoptosis Apoptosis Regulatory Proteins Colonic Diseases Endometriosis Inhibitor of Apoptosis Proteins Ovarian Diseases Peritoneal Diseases Rectal Diseases Apoptosis Apoptosis Regulatory Proteins bcl-2-Associated X Protein bcl-2-Associated X Protein Colonic Diseases Colonic Diseases Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 Endometriosis Endometriosis fas Receptor fas Receptor

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