Comparative immunohistochemical studies of endometriosis lesions and endometriotic cysts

Farr Nezhat, Farr R Nezhat, Nezhat FR, Kalir T, Tamara Kalir
Fertility and sterility · 2002 · vol. 78(4) , pp. 820–824 · doi:10.1016/s0015-0282(02)03345-9 · PMID:12372462 · W2092166473
article OA: bronze CC0 ⤵ 27 in-corpus citations
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This study performed comparative immunohistochemical analysis of endometriosis lesions and endometriotic cysts to identify differential protein expression patterns.

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Abstract

ObjectiveTo compare immunohistochemical staining patterns in noncystic and cystic endometriosis lesions.DesignExperimental.SettingArchived pathology material in an academic research environment.Patient(s)Endometriosis tissues from the pathology archives including slide tissue sections and blocks.Intervention(s)None; this was a retrospective study.Main outcome measure(s)Immunohistochemical staining of the tissues was performed using anti-bcl-2, anti-p53, anti-matrix metalloproteinase IX, and anti-collagen VI antibodies. Staining was qualitatively assessed in terms of extent and intensity.Result(s)p53 showed no staining in both groups. Anti-bcl-2 stained 100% (30/30) of endometriosis lesions compared with only 23% (7/30) of endometriotic cysts (P<.0001), and anti-matrix metalloproteinase IX stained 85% (23/27) of endometriosis lesions and only 39% (14/36) of endometriotic cysts (P=.0003). Anti-collagen VI, however, stained only 6% (2/35) of endometriosis lesions and 75% (21/28) of endometriotic cysts (P<.0001).Conclusion(s)Compared with endometriosis lesions, endometriotic cysts display different expression of proteins with relative overexpression of collagen VI and underexpression of bcl-2 and metalloproteinase IX. This report is the first comparative immunohistochemical study showing these differences.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Immunohistochemistry Ovarian Cysts Collagen Type VI Collagen Type VI Endometriosis Female Humans Matrix Metalloproteinase 9 Matrix Metalloproteinase 9 Ovarian Cysts Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-bcl-2 Retrospective Studies Tumor Suppressor Protein p53 Tumor Suppressor Protein p53

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