Comparative immunohistochemical studies of endometriosis lesions and endometriotic cysts

Farr Nezhat, Farr R Nezhat, Nezhat FR, Kalir T, Tamara Kalir
Fertility and sterility · 2002 · vol. 78(4) , pp. 820–824 · doi:10.1016/s0015-0282(02)03345-9 · PMID:12372462 · W2092166473
Other OA: bronze CC0 ⤵ 27 in-corpus citations
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This study performed comparative immunohistochemical analysis of endometriosis lesions and endometriotic cysts to identify differential protein expression patterns.

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Abstract

OBJECTIVE: To compare immunohistochemical staining patterns in noncystic and cystic endometriosis lesions. DESIGN: Experimental. SETTING: Archived pathology material in an academic research environment. PATIENT(S): Endometriosis tissues from the pathology archives including slide tissue sections and blocks. INTERVENTION(S): None; this was a retrospective study. MAIN OUTCOME MEASURE(S): Immunohistochemical staining of the tissues was performed using anti-bcl-2, anti-p53, anti-matrix metalloproteinase IX, and anti-collagen VI antibodies. Staining was qualitatively assessed in terms of extent and intensity. RESULT(S): p53 showed no staining in both groups. Anti-bcl-2 stained 100% (30/30) of endometriosis lesions compared with only 23% (7/30) of endometriotic cysts (P<.0001), and anti-matrix metalloproteinase IX stained 85% (23/27) of endometriosis lesions and only 39% (14/36) of endometriotic cysts (P=.0003). Anti-collagen VI, however, stained only 6% (2/35) of endometriosis lesions and 75% (21/28) of endometriotic cysts (P<.0001). CONCLUSION(S): Compared with endometriosis lesions, endometriotic cysts display different expression of proteins with relative overexpression of collagen VI and underexpression of bcl-2 and metalloproteinase IX. This report is the first comparative immunohistochemical study showing these differences.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Immunohistochemistry Immunohistochemistry Ovarian Cysts Collagen Type VI Collagen Type VI Collagen Type VI Endometriosis Endometriosis Female Female Humans Humans Matrix Metalloproteinase 9 Matrix Metalloproteinase 9 Matrix Metalloproteinase 9 Ovarian Cysts Ovarian Cysts Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-bcl-2

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (26)

Cited by (27)

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