Expression of tyrosine kinase receptor B in eutopic endometrium of women with adenomyosis

Yaqin Huang, Wei Zheng, Lin Mu, Yuefang Ren, Xuejun Chen, Fang Liu
Archives of gynecology and obstetrics · 2010 · vol. 283(4) , pp. 775–780 · doi:10.1007/s00404-010-1718-4 · PMID:21079983 · W2013662014
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

Tyrosine kinase receptor B (TrkB) protein and mRNA expression are elevated in the secretory endometrium of women with adenomyosis, correlating positively with serum CA125 and dysmenorrhea.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated whether tyrosine kinase receptor B (TrkB) is expressed in eutopic (non-ectopic) endometrium of women with adenomyosis and whether its expression relates to clinical characteristics. Endometrial tissues were collected from 31 women with adenomyosis and 30 adenomyosis-free controls undergoing surgery for benign indications, and TrkB levels were measured by immunohistochemistry and reverse-transcription PCR. TrkB protein and mRNA expression were significantly higher in the secretory-phase endometrium of women with adenomyosis than in controls, and TrkB protein levels correlated positively with serum CA125 and dysmenorrhea; a limitation is the relatively small sample size and focus on surgical specimens from benign-indication patients. This paper is centrally about endometriosis? No—it is centrally about adenomyosis—showing elevated TrkB expression in eutopic endometrium of women with adenomyosis and associations with CA125 and dysmenorrhea.

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Condition tags

dysmenorrheaendometriosisadenomyosis

MeSH descriptors

CA-125 Antigen Dysmenorrhea Endometriosis Endometrium Membrane Proteins Receptor, trkB Adult CA-125 Antigen Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometriosis Endometrium Female Humans Immunohistochemistry Membrane Proteins Middle Aged Pain Measurement

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