Apoptosis pattern in human endometrium in women with pelvic endometriosis
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This study investigated the pattern of apoptosis within the human endometrium of women diagnosed with pelvic endometriosis.
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Abstract
ObjectiveIn the present study we aimed to describe apoptosis patterns in eutopic endometrium in women suffering from endometriosis in order to assess its value as a marker of early forms of endometriosis, and also to try to answer whether endometriosis is caused by changes within the eutopic endometrium or whether endometriotic lesions change the characteristics of eutopic endometrium.Study designThe study was performed on 125 women treated in Division of Reproduction. In 52 patients peritoneal endometriosis was diagnosed (I(0)-23; II(0)-29). Seventy-three patients in whom no endometriotic foci could be found at laparoscopy were qualified as the control group. Endometrial biopsy 7-9 days after ovulation was taken for assessment of apoptosis (TUNEL) and routine histology.ResultsApoptosis indices in the eutopic endometrium of women with endometriosis were lower compared to women without endometriosis. In the endometrial glands apoptosis indices were 2.94+/-1.66 versus 5.23+/-2.06 (p<0.01) in the group of women with and without endometriosis, respectively. In the endometrial stroma apoptosis indices were estimated at 2.04+/-1.72 in women with endometriosis and 4.12+/-1.62 in the control group (p<0.01).ConclusionsThe observed changes could support the hypothesis of the different properties of eutopic endometrium in endometriotic women as a causing factor of peritoneal endometriosis.
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- Comparison of total and endometrial circulating cell-free DNA in women with and without endometriosis 2021
- Catecholestradiol Activation of Adrenergic Receptors Induces Endometrial Cell Survival via p38 MAPK Signaling 2020
- Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies 2020
- Endometriosis: What is the Influence of Immune Cells? 2020
- Phytochemical characteristics from Phaleria macrocarpa and its inhibitory activity on the peritoneal damage of endometriosis 2020
- Suppressive Effects of Ursolic Acid on Human Endometriotic Stromal Cells Survival 2019
- Anti-inflammatory cytokines in endometriosis 2019
- Estrogen restricts the apoptosis of endometrial stromal cells by promoting TSLP secretion 2018
- Endometrial biomarkers for the non-invasive diagnosis of endometriosis 2016
- Activated Hippo/Yes-Associated Protein Pathway Promotes Cell Proliferation and Anti-apoptosis in Endometrial Stromal Cells of Endometriosis 2016
- Innovative approach in assessing the role of neurogenesis, angiogenesis, and lymphangiogenesis in the pathogenesis of external genital endometriosis 2016
- Caracterização morfológica da endometriose ovariana 2016
- Development of peritoneal endometriosis: Characterisation of immune environment in peritoneal endometriotic lesions 2015
- TLR4 Activation Promotes the Secretion of IL-8 Which Enhances the Invasion and Proliferation of Endometrial Stromal Cells in an Autocrine Manner via the FAK Signal Pathway 2015
- The Role of the Lymphatic System in Endometriosis: A Comprehensive Review of the Literature1 2015
- 1,25‐Dihydroxy Vitamin D3 Modulates Endometriosis‐Related Features of Human Endometriotic Stromal Cells 2015
- Clinical markers of endometriosis: Have we been too quick to judge? 2014
- Roles of regulatory T cells in endometriosis-associated infertility 2014
- Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts 2013
- Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis 2013
- MiR-195 inhibits proliferation and growth and induces apoptosis of endometrial stromal cells by targeting FKN. 2013
- Angiogenesis lymphangiogenesis and neurogenesis in endometriosis 2013
- Müllerian Inhibiting Substance Induces Apoptosis of Human Endometrial Stromal Cells in Endometriosis 2012
- CXCL8 enhances proliferation and growth and reduces apoptosis in endometrial stromal cells in an autocrine manner via a CXCR1-triggered PTEN/AKT signal pathway 2012
- Apoptosis of ectopic endometrial cells is impaired in women with endometriosis 2012
- Heterogeneity of eutopic endometrium in endometriosis: Implications for fertility 2011
- Apoptosis and bcl-2 expression in ectopic endometrium of patient with endometriosis 2011
- Dysregulation of the Fas/FasL system in mononuclear cells recovered from peritoneal fluid of women with endometriosis 2011
- Peripheral biomarkers of endometriosis: a systematic review 2010
- Expression of tyrosine kinase receptor B in eutopic endometrium of women with adenomyosis 2010
- Apoptosis and endometriosis 2010
- Involvement of resistance to apoptosis in the pathogenesis of endometriosis. 2009
- Anti-apoptotic and pro-apoptotic gene expression evaluated from eutopic endometrium in the proliferative phase of the menstrual cycle among women with endometriosis and healthy controls 2009
- Increased cell proliferation in experimentally induced endometriosis in rabbits 2009
- Endometriosis prophylaxis and treatment with the newly developed xenogenic immunomodulator RESAN in an animal model 2008
- Apoptosis and endometriosis 2007
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