Increased cell proliferation in experimentally induced endometriosis in rabbits

Julio Cesar Rosa-e-Silva, Ana Carolina Japur de Sá Rosa e Silva, Júlio César Rosa e Silva, Sérgio Britto Garcia, Garcia SB, Sergio Britto Garcia, Ana Carolina Japur de Sá Rosa-e-Silva, de Sá Rosa-e-Silva AC, Francisco José Cândido dos Reis, Francisco José Candido-dos-Reis, Omero Benedicto Poli-Neto, Omero Benedicto Poli‐Neto, Ferriani RA, Rui Alberto Ferriani, Antônio Alberto Nogueira, Antonio Alberto Nogueira, Nogueira AA
Fertility and sterility · 2009 · vol. 93(5) , pp. 1637–1642 · doi:10.1016/j.fertnstert.2009.01.126 · PMID:19304285 · W2107618143
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⚙ AI-generated summary by claude@2026-07, 2026-07-09 ⓘ

This study found that experimentally induced endometriotic lesions in rabbits exhibit increased cell proliferation compared to eutopic endometrium, indicating uncontrolled tissue growth.

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Abstract

ObjectiveTo characterize the pattern of cell proliferation and apoptosis of eutopic and ectopic endometrium in rabbits after endometrium implantation for the experimental induction of endometriosis.DesignAnimal experimental study.SettingSector of experimental surgery.Animal(s)Twenty-female New Zealand rabbits.Intervention(s)All animals underwent laparotomy for endometriosis induction by resection of one uterine horn, isolation of the endometrium, and fixation of tissue segment to the pelvic peritoneum. Two groups of 10 animals were sacrificed 4 and 8 weeks after endometriosis induction. The lesion was excised together with the opposite uterine horn for endometrial gland and stroma determination.Main outcome measure(s)Cell proliferation and apoptosis were determined in the eutopic and ectopic endometrium, and the cell proliferation index (CPI) and apoptotic index (AI) were calculated as the number of labeled cells per 1,000 cells. The tissue homeostasis index was the CPI/AI ratio. Glands and stroma were analyzed separately.Result(s)The CPI for ectopic tissue was increased compared with eutopic tissue, but there was no difference in the ectopic lesions between 4 and 8 weeks of induction. Considering only the AI, eutopic and ectopic endometrium did not differ after 4 weeks, but differed significantly in glandular tissue after 8 weeks. The tissue homeostasis index revealed cell proliferation in these tissues, with a CPI/AI more than 1.Conclusion(s)Ectopic lesions seem to have a higher CPI than eutopic endometrium, with uncontrolled tissue growth occurring in induced endometriotic lesions.

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Condition tags

endometriosis

MeSH descriptors

Cell Proliferation Endometriosis Endometrium Animals Apoptosis Disease Models, Animal Endometriosis Endometrium Endometrium Female Homeostasis Rabbits Stromal Cells Stromal Cells Time Factors Up-Regulation

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