The α2β1 and α3β1 integrins do not mediate attachment of endometrial cells to peritoneal mesothelium

Craig A. Witz, Sook Cho, Iris A Montoya-Rodriguez, Robert S. Schenken
In: Fertility and Sterility · 2002 · vol. 78(4) , pp. 796–803 · doi:10.1016/s0015-0282(02)03340-x · PMID:12372459 · W2047249230
article OA: bronze CC0 ⤵ 15 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study investigated the role of α2β1 and α3β1 integrins in endometrial cell attachment to peritoneal mesothelium, finding they do not mediate this interaction.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo evaluate the possible role of mesothelial alpha(2)beta(1) and alpha(3)beta(1) integrins in the attachment of endometrial stromal cells (ESCs) and endometrial epithelial cells (EECs).DesignIn vitro study.SettingUniversity medical center.Patient(s)Women of reproductive age (n = 26).Main outcome measure(s)Mesothelial cells were grown on collagen IV. Endometrial stromal cells and EECs were plated on mesothelial cells for 1 hour. Before plating, mesothelial cells or endometrial cells were incubated with antibodies to alpha2, alpha3, and beta1 integrin subunits. The effect of these antibodies on ESC and EEC binding to collagen IV and collagen I was also examined. The expression of collagen I, collagen IV, fibronectin, and laminin by cultured ESCs and EECs was examined.Result(s)The anti-integrin antibodies had no effect on endometrial binding to mesothelium. The beta1 integrin antibody decreased binding of ESCs and EECs to the collagen matrices. In culture, ESCs and EECs expressed collagen I, collagen IV, fibronectin, and laminin to varying degrees.Conclusion(s)The initial adhesion of ESCs and EECs to mesothelium is not mediated by beta1 integrins. In contrast, ESC and EEC attachment to collagen IV and collagen I, which are present in the submesothelial extracellular matrix, is mediated by beta1 integrins.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (36)

Cited by (15)

Source provenance

openalex
last seen: 2026-05-11T05:49:40.447239+00:00
License: CC0 · commercial use OK