Imatinib decreases endometrial stromal cell transmesothial migration and proliferation in the extracellular matrix of modeled peritoneum

Jason Griffith, Jason S Griffith, Griffith JS, Binkley PA, Peter A Binkley, Peter Binkley, Namir B. Kirma, Kirma NB, Robert S. Schenken, Schenken RS, Witz CA, Craig A. Witz, Rajeshwar R. Tekmal, Tekmal RR
Fertility and sterility · 2010 · vol. 94(7) , pp. 2531–2535 · doi:10.1016/j.fertnstert.2010.04.018 · PMID:20553674 · W2115476730
article OA: closed CC0 ⤵ 6 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Imatinib treatment reduced endometrial stromal cell transmesothelial migration and proliferation within the extracellular matrix of a modeled peritoneal environment.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo characterize imatinib's effect on endometrial stromal cell (ESC) attachment, proliferation, and invasion in modeled peritoneum.DesignIn vitro study.SettingAcademic medical center.Patient(s)Twelve normally cycling women.Intervention(s)Imatinib treatment in ESCs from women without endometriosis.Main outcome measure(s)Rate of ESC attachment, proliferation, and invasion.Result(s)Imatinib treatment at 10 μM had no effect on ESC attachment. Treatment with 0.5 μM, 2 μM, and 10 μM of imatinib reduced ESC proliferation by 30%, 72%, and 76%, respectively. The 0.1 μM dose of imatinib had no effect on proliferation. Treatment with 5 μM and 10 μM of imatinib reduced ESC invasion by 30% and 73%, respectively. The 2 μM dose had no effect on invasion.Conclusion(s)Imatinib treatment reduces ESC proliferation and invasion in modeled peritoneum without altering attachment. Imatinib may have a therapeutic role in endometriosis treatment.

My notes (saved in your browser only)

MeSH descriptors

Cell Proliferation Endometrium Extracellular Matrix Peritoneum Piperazines Pyrimidines Stromal Cells Transendothelial and Transepithelial Migration Antineoplastic Agents Antineoplastic Agents Benzamides Cell Adhesion Cell Adhesion Cell Adhesion Cell Culture Techniques Cell Proliferation Cells, Cultured Down-Regulation Down-Regulation Drug Evaluation, Preclinical

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

Cited by (6)

Source provenance

europepmc
last seen: 2026-07-30T06:25:42.655704+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:17:07.008521+00:00
unpaywall
last seen: 2026-06-13T06:42:57.164913+00:00
License: CC0 · commercial use OK