Non‐hormonal targets underlying endometriosis: A focus on molecular mechanisms

Xiao-Hang Che; Xiaohang Che; Yi-Chen Chen; Chen YC; Yichen Chen; Chen CL; Chun-lin Chen; Chunlin Chen; Xiaolei Ye; Ye XL; Xiao-lei Ye; Hong Zhu; Zhu H

doi:10.1002/mrd.22493

Non‐hormonal targets underlying endometriosis: A focus on molecular mechanisms

Xiao-Hang Che, Xiaohang Che, Yi-Chen Chen, Chen YC, Yichen Chen, Chen CL, Chun-lin Chen, Chunlin Chen, Xiaolei Ye, Ye XL, Xiao-lei Ye, Hong Zhu, Zhu H

Molecular reproduction and development · 2015 · vol. 82(6) , pp. 410–431 · doi:10.1002/mrd.22493 · PMID:25982890 · W1525857837

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This review examines non-hormonal molecular mechanisms underlying endometriosis and pre-clinical compounds targeting signaling defects for improved treatment understanding.

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Abstract

Endometriosis is regarded as a hormone-dependent disease. Current therapeutic approaches to treating this common gynecological disorder mainly depend on surgical and hormonal interventions, but the high rate of disease recurrence as well as the side effects related to such therapies make it difficult for patients to recover completely. Molecular evidence has recently suggested that the source of endometriosis can be both hormone-dependent and influenced by the dysregulation of some signaling cascades. In this review, we focus on the non-hormonal triggers of endometriosis and the pre-clinical compounds designed to correct these signaling defects in order to achieve a better understanding of the disease as well as novel approaches to treating it.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Signal Transduction Animals Endometriosis Endometriosis Female Humans

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References (100)

Cited by (5)

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