Effects of amifostine on endometriosis, comparison with N-acetyl cysteine, and leuprolide as a new treatment alternative: a randomized controlled trial

Gogsen Onalan, Göğşen Önalan, Cagri Gulumser, Çağrı Gülümser, Barıs Mulayim, Barış Mülayim, Atilla Dagdeviren, Attila Dağdeviren, Hulusi Bülent Zeyneloğlu, Hulusi Zeyneloglu
Archives of gynecology and obstetrics · 2013 · vol. 289(1) , pp. 193–200 · doi:10.1007/s00404-013-2963-0 · PMID:23880890 · W2045861480
article OA: closed CC0 ⤵ 12 in-corpus citations
Limited metadata. Only one source feed has indexed this record so far — no abstract, full text, or open-access copy is available through Endo Lab. The publisher's page (linked below) is the canonical location for the actual content. If you have institutional access, use "Find at my library".
View at publisher → View on OpenAlex View on PubMed
⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Amifostine, N-acetyl cysteine, and leuprolide reduced endometriosis implant size and TNF-alpha levels in rats, with NAC showing the greatest reduction.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This prospective randomized animal study evaluated the effects of amifostine, N-acetyl cysteine (NAC), and leuprolide on regression of endometriosis in 40 rats, using autologous endometrial tissue fragments transplanted to the abdominal wall and assessed after 3 weeks. After confirming implant growth, animals received amifostine, NAC, leuprolide, or no treatment, and investigators measured implant areas morphologically, serum and peritoneal TNF-alpha levels, and performed transmission electron microscopy of peritoneal samples and ovaries. All three drug groups showed significant decreases in mean implant areas and TNF-alpha, with greater TNF-alpha/area reductions in the NAC group and leuprolide appearing to best preserve peritoneal ultrastructure. The authors note the mechanism of regression was “yet unsettled,” and the work is limited to an experimental rat model. This paper is centrally about endometriosis — it is a randomized controlled trial comparing amifostine, NAC, and leuprolide for regression of endometriotic implants in rats.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Acetylcysteine Amifostine Endometriosis Leuprolide Peritoneal Diseases Peritoneum Abdominal Wall Acetylcysteine Amifostine Animals Disease Models, Animal Endometriosis Endometrium Endometrium Female Leuprolide Peritoneal Diseases Peritoneum Random Allocation Rats

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (52)

Cited by (12)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:18:53.335890+00:00
License: CC0 · commercial use OK