Comparing the effect of adjunctive N-acetylcysteine plus low dose contraceptive with low dose contraceptive alone on recurrence of ovarian endometrioma and chronic pelvic pain after conservative laparoscopic surgery: a randomised clinical trial study

Zahra Asgari, Asgari Z, Moini A, Ashraf Moini, Ali Montazeri, Zahra Tavoli, Ladan Hosseini, Hosseini L, Reihaneh Hosseini, Hosseini R, Afsaneh Tehranian, Rana Karimi
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2022 · vol. 42(5) , pp. 1493–1497 · doi:10.1080/01443615.2021.2006165 · PMID:34994286 · W4206338924
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This randomized trial found that adding N-acetylcysteine to low-dose contraceptives resulted in similar reductions in endometrioma recurrence and pelvic pain compared to low-dose contraceptives alone post-surgery.

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Abstract

This study aimed to compare the effectiveness of NAC plus low dose contraceptive with low dose contraceptives alone. This was a randomised trial on a sample of women who underwent conservative laparoscopic surgery for ovarian endometrioma. Patients were randomly assigned either to the NAC plus low dose contraceptive group (n = 48) or low dose contraceptive alone (n = 52). To evaluate the recurrence rate transvaginal ultrasound was performed. Pelvic pain was assessed using a visual analogue scale (VAS). All assessments were performed at two points in time: 3 and 6 months post-surgery and compared between the two regimens. The findings indicated that reduction in the recurrence rate of endometrioma and pelvic pain were similar between both groups. The findings showed that adding N-acetylcysteine to low dose contraceptive treatment has a similar effect in reducing the recurrence rate of endometrioma and pelvic pain when compared to low dose contraceptives alone.Impact statementWhat is already known on this subject? Endometriosis is a frequent benign disease-producing inflammatory response with mild to severe symptoms. Although surgical removal of ectopic lesions is the first-line intervention, the recurrence rate of the disease is high. Thus this study aimed to compare the effectiveness of N-acetylcysteine plus low dose contraceptive with low dose contraceptive alone.What do the results of this study add? The findings showed that adding N-acetylcysteine to low dose contraceptive treatment has a similar effect in reducing the recurrence rate of endometrioma and pelvic pain when compared to low dose contraceptives alone.What are the implications of these findings for clinical practice and/or further research? It is recommended to increase the duration of drug administration in future studies

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Outcome instruments

VAS-pain

Condition tags

endometriosischronic_pelvic_painendometrioma

MeSH descriptors

Chronic Pain Endometriosis Endometriosis Endometriosis Laparoscopy Ovarian Diseases Ovarian Diseases Acetylcysteine Acetylcysteine Contraceptive Agents Female Humans Pelvic Pain Pelvic Pain Pelvic Pain Pelvic Pain Recurrence

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