More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis

Pittaluga E, Eugenia Pittaluga, Costa G, Graziella Costa, Ewa K. Krasnowska, Ewa Krasnowska, Roberto Brunelli, Brunelli R, Lundeberg T, Thomas Lundeberg, Maria Grazia Porpora, Daniela Santucci, Santucci D, Tiziana Parasassi
Fertility and sterility · 2010 · vol. 94(7) , pp. 2905–2908 · doi:10.1016/j.fertnstert.2010.06.038 · PMID:20655527 · W1998166334
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This study investigated the non-antioxidant effects of N-acetyl-L-cysteine on endometriosis in a mouse model.

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Abstract

N-acetyl-L-cysteine exerts a complex action on endometrial cells, involving regulation of gene expression and protein activity and location, all converging into a decreased proliferation and a switch toward a differentiating, less invasive, and less inflammatory phenotype. Also considering the lack of undesired side effects, including unaffected fertility potential, this suggests a beneficial use of NAC in endometriosis clinical treatment.

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Condition tags

endometriosis

MeSH descriptors

Acetylcysteine Antioxidants Disease Models, Animal Endometriosis Mice Peritoneal Diseases Acetylcysteine Acetylcysteine Animals Antioxidants Antioxidants Cell Differentiation Cell Differentiation Cell Differentiation Cell Movement Cell Movement Cell Movement Cell Proliferation Cell Proliferation Cytostatic Agents

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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