More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis
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⤵ 36 in-corpus citations
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This study investigated the non-antioxidant effects of N-acetyl-L-cysteine on endometriosis in a mouse model.
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Abstract
N-acetyl-L-cysteine exerts a complex action on endometrial cells, involving regulation of gene expression and protein activity and location, all converging into a decreased proliferation and a switch toward a differentiating, less invasive, and less inflammatory phenotype. Also considering the lack of undesired side effects, including unaffected fertility potential, this suggests a beneficial use of NAC in endometriosis clinical treatment.
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Cited by (40)
- The Role of Dietary Supplements in the Treatment of Endometriosis: A Critical Review 2026
- Einsatz von Komplementärmedizin in der Behandlung von Endometriose 2026
- Beyond antioxidant activity, toward redox modulation: N-acetylcysteine (NAC) in endometriosis and uterine leiomyomas 2026
- N-Acetylcysteine in Endometriosis: A Systematic Review of Biological Rationale and Clinical Evidence 2026
- PRMT3-mediated FOXO1 arginine methylation exacerbates oxidative stress-induced decidualization defects in the eutopic endometrium of endometriosis 2025
- PRMT3-mediated FOXO1 arginine methylation exacerbates oxidative stress-induced decidualization defects in the eutopic endometrium of endometriosis 2025
- Targeting inflammation in endometriosis: emerging therapeutic options 2025
- D-chiro-inositol effectively counteracts endometriosis in a mouse model 2025
- Oxidative Imbalance in Endometriosis-Related Infertility-The Therapeutic Role of Antioxidants 2024
- Ferroptosis and oxidative stress in endometriosis: A systematic review of the literature 2024
- Peritoneal immune microenvironment of endometriosis: Role and therapeutic perspectives 2023
- Efficacy of N-Acetylcysteine on Endometriosis-Related Pain, Size Reduction of Ovarian Endometriomas, and Fertility Outcomes 2023
- Hypovitaminosis E and Endometriosis in a Sub-Saharan Population 2023
- Photoacoustic Imaging Endometriosis Lesions with Nanoparticulate Polydopamine as a Contrast Agent 2023
- Comparing the effect of adjunctive N-acetylcysteine plus low dose contraceptive with low dose contraceptive alone on recurrence of ovarian endometrioma and chronic pelvic pain after conservative laparoscopic surgery: a randomised clinical trial study 2022
- Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis 2022
- Targeting Oxidative Stress Involved in Endometriosis and Its Pain 2022
- Role of AMPK/mTOR, mitochondria, and ROS in the pathogenesis of endometriosis 2022
- Endometriosis in the Mouse: Challenges and Progress Toward a 'Best Fit' Murine Model 2022
- Dietary supplements for treatment of endometriosis: A review 2022
- Oxidative stress-related effects on various aspects of endometriosis 2022
- Endometriosis in the Mouse: Challenges and Progress Toward a 'Best Fit' Murine Model 2022
- Can Endometriosis-Related Oxidative Stress Pave the Way for New Treatment Targets? 2021
- Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review 2021
- RNA sequencing-based long non-coding RNA analysis and immunoassay in ovarian endometriosis 2020
- Endometriosis Is a Cause of Infertility. Does Reactive Oxygen Damage to Gametes and Embryos Play a Key Role in the Pathogenesis of Infertility Caused by Endometriosis? 2018
- Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study 2018
- The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner 2018
- Self-management and psychological-sexological interventions in patients with endometriosis: strategies, outcomes, and integration into clinical care 2017
- Alteration of Nrf2 and Glutamate Cysteine Ligase expression contribute to lesions growth and fibrogenesis in ectopic endometriosis 2017
- Viburnum opulus L.: A remedy for the treatment of endometriosis demonstrated by rat model of surgically-induced endometriosis 2016
- An overview of early drug development for endometriosis 2015
- Novel Medical Treatment Modalities of Endometriosis 2015
- Targeting oxidative stress to treat endometriosis 2015
- Nutritional aspects related to endometriosis 2015
- Oxidation-sensitive nociception involved in endometriosis-associated pain 2015
- The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis 2015
- Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model 2015
- A promise in the treatment of endometriosis: an observational cohort study on ovarian endometrioma reduction by N-acetylcysteine 2013
- Etude phénotypique des cellules endométriosiques profondes 2012
Source provenance
- europepmc
- last seen: 2026-10-15T06:08:49.021275+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:07:47.794683+00:00
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