Die Bedeutung des Tumornekrosefaktors Alpha (TNF-Alpha) bei der Endometriose

W Küpker, Küpker W, Felberbaum R, R Felberbaum, Bauer O, O Bauer, K Diedrich, Diedrich K
Geburtshilfe und Frauenheilkunde · 1996 · vol. 56(05) , pp. 239–242 · doi:10.1055/s-2007-1022267 · PMID:8768061 · W2074757074
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This study found higher concentrations of TNF-alpha in the peritoneal fluid of women with endometriosis, with levels increasing with disease activity and severity.

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The paper studied whether peritoneal concentrations of tumor necrosis factor alpha (TNF-α), a macrophage-derived cytokine involved in angiogenesis and immunoregulation, differ in women with endometriosis compared with those with an unremarkable genital status. At a high level, it compared TNF-α levels in peritoneal fluid across different endometriosis activity states (active vs inactive) and across severities, including rAFS stage III–IV. The key finding was that TNF-α concentrations were higher in endometriosis, higher in active than inactive disease, and highest in severe endometriosis (rAFS III/IV), with the caveat implied by the scope being that the study focuses on peritoneal fluid TNF-α measurements rather than causal mechanisms. This paper is centrally about endometriosis — it specifically analyzes TNF-α concentrations in peritoneal fluid across disease activity and severity in endometriosis.

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Abstract

Macrophage-derived substances such as cytokines and growth promoting factors are known to be present in the peritoneal fluid of women with endometriosis. Active endometriosis of the peritoneum is characterised by hypervascularization and neoangiogenesis. TNF-alpha is a pleiotropic cytokine also involved in angiogenesis and immunoregulation. Our question was to determine whether there are differences in the peritoneal TNF-alpha concentrations in women with various degrees of active and inactive endometriosis. We found that TNF-alpha concentrations were higher in the peritoneal fluid of women with endometriosis than in the peritoneal fluid of those without. TNF-alpha concentrations were higher in cases of active endometriosis than in cases of inactive endometriosis. The highest concentrations could be detected in women with severe endometriosis (stage III and IV rAFS).
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Subscribe to RSS DOI: 10.1055/s-2007-1022267 © Georg Thieme Verlag Stuttgart · New York Die Bedeutung des Tumornekrosefaktors Alpha (TNF-Alpha) bei der Endometriose Tumour Necrosis Factor Alpha and EndometriosisPublication History Publication Date: 17 June 2008 (online) Zusammenfassung Makrophagen produzieren eine Reihe immunaktiver und proliferationsfördernder Substanzen wie Cytokine und Wachstumsfaktoren. Eine Vielzahl solcher Substanzen konnte in der Peritonealflüssigkeit von Frauen mit Endometriose nachgewiesen werden. Eine aktive Endometriose des Peritoneums ist durch HyperVaskularisation und Neoangiogenese charakterisiert. TNF-alpha ist ein Cytokin, das eine zentrale Bedeutung in der Angiogenese und der Immunregulation hat. Ziel unserer Untersuchung war herauszufinden, ob höhere Konzentrationen von TNF-alpha im Peritonealsekret von Frauen mit Endometriose nachweisbar sind, und ob unterschiedliche Aktivitätsgrade der Endometriose mit unterschiedlichen Konzentrationen von TNF-alpha im Peritonealsekret verbunden sind. Wir fanden heraus, daß bei Frauen mit Endometriose höhere Konzentrationen von TNF-alpha meßbar waren als bei Frauen mit unauffälligem gesunden Genitalsitus. Die Konzentrationen waren deutlich höher in Fällen von aktiver Endometriose als in Fällen inaktiver Endometriose. Die höchsten Konzentrationen konnten bei Frauen mit einer schweren Endometriose (entsprechend Stadium III und IV nach rAFS) gemessen werden. Abstract Macrophage - derived substances such as cytokines and growth promoting factors are known to be present in the peritoneal fluid of women with endometriosis. Active endometriosis of the Peritoneum is characterised by hypervascularisation and neoangiogenesis. TNF-alpha is a pleiotropic cytokine also involved in angiogenesis and immunoregulation. Our question was to determine whether there are differences in the peritoneal TNF-alpha concentrations in women with various degrees of active and inactive endometriosis. We found that TNF-alpha concentrations were higher in the peritoneal fluid of women with endometriosis than in the peritoneal fluid ot those without. TNF-alpha concentrations were higher in cases of active endometriosis than in cases of inactive endometriosis. The highest concentrations could be detected in women with severe endometriosis (stage III and IV rAFS).

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Ascitic Fluid Endometriosis Peritoneum Tumor Necrosis Factor-alpha Adult Ascitic Fluid Endometriosis Female Humans Laparoscopy Neovascularization, Pathologic Neovascularization, Pathologic Peritoneum Peritoneum Reference Values Tumor Necrosis Factor-alpha

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (11)

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