Die Bedeutung des Tumornekrosefaktors Alpha (TNF-Alpha) bei der Endometriose
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This study found higher concentrations of TNF-alpha in the peritoneal fluid of women with endometriosis, with levels increasing with disease activity and severity.
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Abstract
Macrophage-derived substances such as cytokines and growth promoting factors are known to be present in the peritoneal fluid of women with endometriosis. Active endometriosis of the peritoneum is characterised by hypervascularization and neoangiogenesis. TNF-alpha is a pleiotropic cytokine also involved in angiogenesis and immunoregulation. Our question was to determine whether there are differences in the peritoneal TNF-alpha concentrations in women with various degrees of active and inactive endometriosis. We found that TNF-alpha concentrations were higher in the peritoneal fluid of women with endometriosis than in the peritoneal fluid of those without. TNF-alpha concentrations were higher in cases of active endometriosis than in cases of inactive endometriosis. The highest concentrations could be detected in women with severe endometriosis (stage III and IV rAFS).
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Cited by (11)
- The Diagnostic Effect of Intraoperative Indocyanine Green Imaging for Endometriosis: A Systematic Review and Meta-Analysis 2024
- Peripheral Biomarkers as Predictive Indicators of Endometriosis: A Prospective Case Control Study 2017
- Effects of amifostine on endometriosis, comparison with N-acetyl cysteine, and leuprolide as a new treatment alternative: a randomized controlled trial 2013
- Endometriose 2004
- Entstehung und Pathogenese 2004
- Rezidivierende Endometriose?ein Kofaktor der vorzeitigen Menopause? 2003
- Endometriosis is sustained by tumour necrosis factor-α 2002
- E- and P-selectin expression in endometriotic tissues and the corresponding endometria 2000
- Endometriosis and Infertility: New Concepts 1999
- Integrin-mediated adhesion of uterine endometrial cells from endometriosis patients to extracellular matrix proteins is enhanced by tumor necrosis factor alpha (TNFα) and interleukin-1 (IL-1) 1999
- Endometriosis and Infertility 1997
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