[TNF-alpha serum levels in women with endometriosis: prospective clinical study].
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This study found significantly higher serum TNF-alpha levels in women with endometriosis compared to those without, suggesting it may be a useful diagnostic marker.
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Abstract
OBJECTIVE: To determine serum levels of TNF-alpha (tumor necrosis factor alpha) as a prediction of endometriosis. DESIGN: Prospective clinical case control study. SETTING: Department of Obstetrics and Gynaecology and Department of Pathology, Jessenius Faculty Hospital, Kollarova 2, Martin, Slovakia. METHODS: The serum TNF-alpha was determined in women who underwent laparoscopy or laparotomy due to pelvic pain, infertility, dysmenorea or pelvic tumor. Endometriosis was confirmed histologically and classified by rAFS. RESULTS: On the basis of entering criteria 65 women were enrolled in this study. In 61 cases serum level of TNF-alpha was evaluated. The average serum level of TNF-alpha in the endometriotic group was 73.847 pg/ml (n=30) and without endometriosis was 21.089 pg/ml (n=31). We have found a significant statistical difference between the above mentioned groups in the medium levels of TNF-alpha (p<0.0001). We did not find statistical significance between TNF-alpha levels and in the group of women with endometriosis in relation to the stage of the disease (I.-II., III.-IV., adenomyosis). At a cut-off level of TNF-alpha 30 pg/ml there was a 63.33% sensitivity, 77.42% specificity, a positive prediction value 73.07%, and 68.57% of negative predictive value. CONCLUSION: TNF-alpha serum levels are good diagnostic markers of endometriosis in the spectrum of noninvasive methods.
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Cited by (20)
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- The Critical Role of Host and Bacterial Extracellular Vesicles in Endometriosis 2024
- Managing the neuroinflammatory pain of endometriosis in light of chronic pelvic pain 2024
- Effects of Quince Gel and Hesperidin Mixture on Experimental Endometriosis 2023
- Sulawesi propolis induces higher apoptotic activity and lower inflammatory activity in a rat endometriosis model 2023
- Modern non-invasive diagnosis of endometriosis 2023
- IN-SILICO dynamic analysis of Sulawesi propolis as anti-endometriosis drug: Interaction study with TNF alpha receptor, NF-kB, estrogen receptor, progesterone receptor and prostaglandin receptor 2021
- Cytokines, Angiogenesis, and Extracellular Matrix Degradation are Augmented by Oxidative Stress in Endometriosis 2020
- The Suppression Effect of Kebar Extract on Endometriosis Lesion MDA and TNF -a Independent to VEGF A Study in Endometriosis Mice Mode 2020
- Effects of clarithromycin on inflammatory markers and clinical manifestations in postsurgical follow-up of patients with endometriosis: a double-blinded randomized placebo-controlled clinical trial 2019
- Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice 2019
- The Differences of Malondialdehyde Serum Level, Expression of Tumor Necrosis Factor Alpha and Vascular Endothelial Growth Factor, and the Area of Endometriotic Implants in Administration of Kebar Grass Extract (Biophytum petersianum) and Green Tea Extract (Camelia sinensis) to Mice 2019
- Serum and peritoneal fluid concentrations of soluble human leukocyte antigen, tumor necrosis factor alpha and interleukin 10 in patients with selected ovarian pathologies 2017
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Risk of developing major depression and anxiety disorders among women with endometriosis: A longitudinal follow-up study 2015
- Roles of regulatory T cells in endometriosis-associated infertility 2014
- Enhanced Inflammatory Activity of Endometriotic Lesions from the Rectovaginal Septum 2013
- Effects of amifostine on endometriosis, comparison with N-acetyl cysteine, and leuprolide as a new treatment alternative: a randomized controlled trial 2013
- Follicular Proinflammatory Cytokines and Chemokines as Markers of IVF Success 2011
- Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample 2007
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