Effects of clarithromycin on inflammatory markers and clinical manifestations in postsurgical follow-up of patients with endometriosis: a double-blinded randomized placebo-controlled clinical trial

Saeed Alborzi, Tahereh Poordast, Elham Askary, Gita Dorniani
Archives of gynecology and obstetrics · 2019 · vol. 299(5) , pp. 1305–1312 · doi:10.1007/s00404-019-05057-4 · PMID:30888478 · W2925157129
article OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study found that clarithromycin reduced endometriosis symptoms and inflammatory markers more than placebo, but the differences were not statistically significant.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This double-blinded randomized placebo-controlled trial studied postsurgical endometriotic women in Shiraz, Iran, assigning participants immediately after surgery to receive clarithromycin 500 mg daily for 6 months (n=120) or placebo (n=169). Serum inflammatory markers (CRP, TNF-α, and IL-10) and clinical pain symptoms (dysmenorrhea, dyschezia, dyspareunia, and non-menstrual pain) were assessed at baseline and at 3 and 6 months. Both groups showed decreases in pain symptoms and inflammatory marker levels versus baseline, but the real and placebo groups did not show significant between-group differences, with reported reductions not depending on time. This paper centrally about endometriosis — it tests whether clarithromycin after surgery improves inflammatory markers and clinical manifestations in endometriosis patients.

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Condition tags

endometriosis

MeSH descriptors

Anti-Bacterial Agents Biomarkers Clarithromycin Endometriosis Adult Anti-Bacterial Agents Anti-Bacterial Agents Biomarkers Clarithromycin Clarithromycin Double-Blind Method Endometriosis Endometriosis Female Follow-Up Studies Humans Middle Aged

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europepmc
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