Endometriosis allergic or autoimmune disease: pathogenetic aspects - a case control study

Donatella Caserta, Caserta D, D Caserta, M Mallozzi, Mallozzi M, Michael Mallozzi, F. M. Pulcinelli, Pulcinelli FM, B Mossa, Mossa B, Moscarini M, Massimo Moscarini, M Moscarini
Clinical and experimental obstetrics & gynecology · 2016 · vol. 43(3) , pp. 354–357 · doi:10.12891/ceog2122.2016 · PMID:27328490 · W2475330636
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

This case-control study found that patients with endometriosis have a higher prevalence of allergies and a co-occurrence of allergies and autoimmune diseases compared to those without endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This retrospective case-control study evaluated whether endometriosis is associated with immune-related conditions, using 304 patients with endometriosis and 318 without endometriosis, with data collected uniformly and analyzed via chi-square tests. The study found that endometriosis patients had a higher prevalence of allergies (p = 0.0003) and a higher coexistence of allergies and autoimmune diseases (p = 0.0274) than those without endometriosis. The paper’s explicit limitation is that it relies on retrospective data collection and does not establish causality, only correlation. This paper is centrally about endometriosis — it assesses the relationship between endometriosis and allergic or autoimmune disease prevalence.

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Abstract

PURPOSE OF INVESTIGATION: The aim of this study was to evaluate the correlation between endometriosis and pathologies on an immune basis for the possible involvement of the immune system in the pathogenesis of endometriosis. MATERIALS AND METHODS: In this retrospective study, data of 304 patients with endometriosis and 318 without endometriosis were collected in a uniform manner for both groups and inserted into two databases, respectively, for patients with and without endometriosis. The authors calculated the percentages of patients with allergies, autoimmune diseases, asthma in both groups, and later statistical analysis were performed with two different chi-square tests. RESULTS: The results obtained have shown that patients with endometriosis have a higher prevalence of allergies (p = 0.0003) and coexistence of both allergies and autoimmune diseases (p = 0.0274), compared to those without. CONCLUSIONS: The present study seems to support the possible association between endometriosis and allergic diseases.
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Abstract

Purpose of investigation: The aim of this study was to evaluate the correlation between endometriosis and pathologies on an immune basis for the possible involvement of the immune system in the pathogenesis of endometriosis. Materials and Methods: In this retrospective study, data of 304 patients with endometriosis and 318 without endometriosis were collected in a uniform manner for both groups and inserted into two databases, respectively, for patients with and without endometriosis. The authors calculated the percentages of patients with allergies, autoimmune diseases, asthma in both groups, and later statistical analysis were performed with two different chisquare tests. Results: The results obtained have shown that patients with endometriosis have a higher prevalence of allergies (p = 0.0003) and coexistence of both allergies and autoimmune diseases (p = 0.0274), compared to those without. Conclusions: The present study seems to support the possible association between endometriosis and allergic diseases.

Keywords

- Endometriosis - Immune system diseases - Allergies - Autoimmune diseases - Asthma

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Condition tags

endometriosis

MeSH descriptors

Asthma Autoimmune Diseases Endometriosis Hypersensitivity Adult Antigen-Presenting Cells Antigen-Presenting Cells Asthma Asthma Autoimmune Diseases Autoimmune Diseases Case-Control Studies Chi-Square Distribution Comorbidity Endometriosis Endometriosis Female Humans Hypersensitivity Hypersensitivity

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