Increased expression of IgE‐dependent histamine‐releasing factor in endometriotic implants

Kosuke Oikawa, Yoshinori Kosugi, Tetsuya Ohbayashi, Akemi Kameta, Keiichi Isaka, Masaomi Takayama, Masahiko Kuroda, Kiyoshi Mukai
The Journal of Pathology · 2003 · vol. 199(3) , pp. 318–323 · doi:10.1002/path.1299 · PMID:12579533 · W2093921841
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Endometriotic implants showed increased expression of histamine-releasing factor (HRF), which was induced by macrophages and enhanced implant growth.

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Abstract

A complex network of cytokines mediates the immunoregulatory responses leading to endometriosis. Recent intensive studies suggest that monocyte and T cell chemoattractants contribute to the inflammatory environment of endometriotic implants. The relationship between the inflammation present during endometriosis and the development of endometriotic implants in the peritoneal cavity remains unclear. On the other hand, the association between endometriosis and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) exposure has been discussed in recent years, and our previous results revealed that IgE-dependent histamine-releasing factor (HRF) is inducible by TCDD. The present study aimed to clarify the expression, localization, and function of HRF in endometriosis. Northern blot analysis demonstrated that HRF is overexpressed in endometriotic implants. RT-PCR with Southern blot analysis, however, showed that HRF overexpression was not always accompanied by CYP1A1 induction in endometriotic implants, suggesting that HRF is inducible in endometriosis without exposure to TCDD. HRF is also inducible by macrophage colony-stimulating factor (M-CSF). Immunohistochemistry showed CD68-positive macrophages in the stroma of endometriotic implants, adjacent to regions with prominent HRF accumulation. HRF-overexpressing cells exhibited high implantation efficiency in comparison to control cells when the cells were injected into the peritoneal cavities of nude mice. These results suggest that the accumulation of macrophages in endometriotic implants induces HRF; the overexpression of HRF accelerates the growth of endometriotic implants.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers, Tumor Endometriosis Immunoglobulin E 3T3 Cells 3T3 Cells Animals Biomarkers, Tumor Biomarkers, Tumor Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A1 Endometriosis Endometriosis Endometrium Endometrium Female Gene Expression Regulation Humans Immunoglobulin E Mice Mice, Inbred BALB C

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