Does Disruption of Immune and Endocrine Systems by Environmental Toxins Contribute to Development of Endometriosis?
Environmental toxins may contribute to endometriosis by disrupting the immune and endocrine systems that regulate endometrial function.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
This article examines how endocrine and immune disruption by environmental toxins could contribute to endometriosis, focusing on the idea that normal endometrium depends on coordinated cell-cell signaling regulated by steroid hormones, cytokines, and growth factors. It argues that toxins can perturb this balance either through direct hormone-disrupting effects (e.g., hormone disruptors) or indirect immune-related effects, potentially altering the endometrium’s steroid responsiveness and leading to pathological states that include endometriosis. A stated caveat is that the work is based on accumulating evidence rather than presenting new experimental results in a specific population. This paper is centrally about endometriosis — it reviews mechanisms by which environmental toxins disrupting immune and endocrine systems may promote endometriosis development.
Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works
Abstract
Full text
944 characters
· extracted from
oa-doi-fallback
· 2 sections
· click to expand
Abstract
Keywords
Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.
My notes (saved in your browser only)
Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
Cited by (34)
- Endometriosis 2019
- Endometriosis 2019
- Endometriosis 2019
- Association between mRNA Expression of Aromatase, 17β-HSD2, Level of TGF-β1 and Stage of Endometriosis 2016
- Asymmetric dimethylarginine (ADMA), nitric oxide metabolite, and estradiol levels in serum and peritoneal fluid in women with endometriosis 2015
- Precancerous Lesions of Ovarian Clear Cell and Endometrioid Carcinomas 2015
- <i>ESR1</i>rs9340799 Is Associated with Endometriosis-Related Infertility and<i>In Vitro</i>Fertilization Failure 2013
- Progesterone Action in Endometrial Cancer, Endometriosis, Uterine Fibroids, and Breast Cancer 2013
- Antiangiogenic agents for endometriosis 2011
- Developmental dioxin exposure and endometriosis 2011
- Gonadotropin-releasing hormone agonist and add-back therapy: what do the data show? 2010
- Endometriosis 2009
- High plasma concentrations of polychlorinated biphenyls and phthalate esters in women with endometriosis: a prospective case control study 2006
- Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis 2006
- General gynaecology: Association of phthalate esters with endometriosis in Indian women 2006
- Endometriosis 2005
- Aromatase in endometriosis and uterine leiomyomata 2005
- The Link between Exposure to Dioxin and Endometriosis: A Critical Reappraisal of Primate Data 2004
- Increased expression of IgE‐dependent histamine‐releasing factor in endometriotic implants 2003
- High plasma concentrations of di-(2-ethylhexyl)-phthalate in women with endometriosis 2003
- Treatment with Aromatase Inhibitors 2003
- Mechanisms of excessive estrogen formation in endometriosis 2002
- Estrogen Production and Metabolism in Endometriosis 2002
- Tampons, dioxins, and endometriosis 2001
- Expression of Scavenger Receptor Class B1 in Endometrium and Endometriosis 2001
- The risk of endometriosis and exposure to dioxins and polychlorinated biphenyls: a case–control study of infertile women 2001
- Increased Insulin-like Growth Factor 1 Activity Can Rescue KLE Endometrial-like Cells from Apoptosis 2001
- Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues 2000
- Aromatase as a Therapeutic Target in Endometriosis 2000
- Endometriosis: An Overview of the Disease and Its Treatment 2000
- Possible involvement of arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1 genes in the development of endometriosis 1999
- Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target 1999
- Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target 1999
- The Potential Role of Environmental Toxins in the Pathophysiology of Endometriosis 1999
Source provenance
- europepmc
- last seen: 2026-08-23T09:30:01.253652+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:10:52.568893+00:00
- unpaywall
- last seen: 2026-08-23T06:29:45.520198+00:00