C-reactive protein of serum and peritoneal fluid in endometriosis.

Maryam Kianpour, Mehdi Nematbakhsh, Sayad Mehdi Ahmadi
Iranian journal of nursing and midwifery research · 2012 · vol. 17(2 Suppl 1) , pp. S115–9 · PMID:23833592 · W2205718496
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This study found no significant difference in serum C-reactive protein levels between endometriosis patients and controls, but peritoneal fluid C-reactive protein was significantly higher in endometriosis patients.

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Abstract

BACKGROUND: Endometriosis is defined as the existence of endometrial-like tissue outside the uterus. Diagnosis of endometriosis is a challenging theme. Despite the broad search for innovative laboratory tests and advances in imaging technologies, there are still no easy, non-invasive diagnostic tests available. Due to inflammatory process of endometriosis, still C-reactive protein (CRP) level may be the target of initial screening. The aim of this study was to investigate CRP levels as a marker of inflammatory process in serum and peritoneal fluid of patients with endometriosis. MATERIALS AND METHODS: In a case control study, 179 patients with endometriosis (N = 90) and without endometriosis (N = 89) were evaluated. The venous blood samples were obtained from all patients before laparoscopy and the peritoneal fluid samples were collected from pelvis before any manipulation. Student's t-test was applied to compare the parameters between two groups. FINDINGS: There was no significant difference between the CRP serum level in patients with endometriosis and infertile women without endometriosis. There was a significant difference in peritoneal level of CRP between case and control groups (p < 0.05). CONCLUSIONS: The findings suggested that measurement of this marker in patients' serum or plasma cannot be used to diagnose endometriosis. It is further recommended that a combination of different markers might be helpful in this regard that could be studied in future.

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endometriosis

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