Atorvastatin exerts anti-nociceptive activity and decreases serum levels of high-sensitivity C-reactive protein and tumor necrosis factor-α in a rat endometriosis model

Yavuz Şimşek, Yavuz Simsek, Mehmet Gul, Mehmet Gül, Ercan Yilmaz, Ercan Yılmaz, Ibrahim Halil Ozerol, İbrahim Halil Özerol, Elif Ozerol, Elif Özerol, Hakan Parlakpınar, Hakan Parlakpinar
Archives of gynecology and obstetrics · 2014 · vol. 290(5) , pp. 999–1006 · doi:10.1007/s00404-014-3295-4 · PMID:24913463 · W1993903035
article OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Atorvastatin treatment demonstrated analgesic activity and reduced serum hs-CRP and TNF-α levels in a rat endometriosis model.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper studied the effects of atorvastatin on experimental endometriosis in 24 female rats, comparing daily atorvastatin (10 mg/kg for 14 days) with leuprolide acetate (1 mg/kg) and saline controls after endometriosis induction. The authors assessed endometriotic focus dimensions and performed biochemical, histopathological, and immunohistochemical analyses, along with nociception testing using a hot plate model. Atorvastatin produced significant analgesic activity and significantly reduced serum high-sensitivity C-reactive protein and tumor necrosis factor-α levels, with lower histologic and immunohistochemical scores versus controls. The main caveat is that this is an animal model with short-term dosing and no explicit discussion of translation limits to humans. This paper is centrally about endometriosis — it evaluates atorvastatin’s anti-nociceptive and anti-inflammatory effects in a rat endometriosis model.

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Condition tags

endometriosis

MeSH descriptors

Analgesics C-Reactive Protein Endometriosis Heptanoic Acids Leuprolide Pyrroles Tumor Necrosis Factor-alpha Analgesics Animals Atorvastatin C-Reactive Protein C-Reactive Protein Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Schedule Endometriosis Endometriosis Endometrium Endometrium Female

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