Medical treatments for endometriosis.
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⤵ 15 in-corpus citations
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This review discusses current medical and surgical treatments for endometriosis, including hormonal therapies and novel agents like aromatase inhibitors, while acknowledging the need for further research on efficacy and safety.
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Abstract
Despite the extensive research, endometriosis remains an enigmatic disease as up to now there is no consensus regarding the exact underlying mechanisms which could explain its development and progress. A local environment enriched in estrogens, progesterone resistance, local inflammatory response and multiple other molecular alterations appear to be pivotal events in the establishment and development of ectopic tissue. In the light of the evidence produced by molecular pathology research, in vivo and in vitro studies, modifications in current treatment options are anticipated. Current management of endometriosis is based on pharmacologic treatment and surgical intervention. In particular, combined oral contraceptives, danazol, gonadotropin-releasing hormone (GnRH) analogues and progestins have been extensively used in clinical practice. Novel agents that will hopefully improve the therapeutic potential include aromatase inhibitors, immunomodulators, anti-inflammatory agents, steroids receptor modulators and GnRH antagonists. It is still early for enthusiasm as there is limited knowledge about their short- and long-term side effects, their optimal administration route, their selectivity towards their target genes and the duration of treatment. Although there is a continual report of novel findings, the application of them in clinical practice is a long-lasting procedure requiring longitudinal clinical trials so as to achieve a balance between efficacy and safety.
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Cited by (15)
- Time to full effect, following treatment with combined oral contraceptives (cyclic versus continuous administration) in patients with endometriosis after laparoscopic surgery: a prospective cohort study 2020
- Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis 2018
- Stem Cell Markers Describe a Transition From Somatic to Pluripotent Cell States in a Rat Model of Endometriosis 2017
- From the history of studies of endometriosis to current treatments 2016
- Novel Medical Treatment Modalities of Endometriosis 2015
- The Effectiveness of Phalleria macrocarpa Bioactive Fraction in Alleviating Endometriosis and/or Adenomyosis Related Pain 2015
- On-label and off-label drug use in the treatment of endometriosis 2015
- Is adenomyosis a problem in reproduction and fertility? 2014
- Perioperative Outcomes of Robotic Assisted Laparoscopic Surgery Versus Conventional Laparoscopy Surgery for Advanced-Stage Endometriosis 2014
- Pregnancy affects morphology of induced endometriotic lesions in a mouse model through alteration of proliferation and angiogenesis 2014
- Atorvastatin exerts anti-nociceptive activity and decreases serum levels of high-sensitivity C-reactive protein and tumor necrosis factor-α in a rat endometriosis model 2014
- Anatomy, Development, Histology, and Normal Function of the Ovary 2014
- Continuous versus cyclic use of oral contraceptives after surgery for symptomatic endometriosis: a prospective cohort study 2013
- The ENDOCARE questionnaire guides European endometriosis clinics to improve the patient-centeredness of their care 2012
- The role of tissue factor and protease‐activated receptor 2 in endometriosis 2012
SciLite annotations
chemicals 4
estrone
progesterone
danazol
progestin
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