Stem Cell Markers Describe a Transition From Somatic to Pluripotent Cell States in a Rat Model of Endometriosis

Essam Rashad Othman, Essam R. Othman, Fatma Yassine Meligy, Fatma Y. Meligy, Ayat Abdel-Rahman Sayed, Ayat A. Sayed, Mohamed Ahmed El-Mokhtar, Mohamed A. El‐Mokhtar, Abeer Mohamed Refaiy, Abeer M. Refaiy
Reproductive sciences (Thousand Oaks, Calif.) · 2017 · vol. 25(6) , pp. 873–881 · doi:10.1177/1933719117697124 · PMID:28325116 · W2598260857
article OA: closed CC0 ⤵ 10 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-10 ⓘ

In a rat endometriosis model, ectopic endometrium showed increased Oct4 and SSEA1 gene and protein expression compared to control endometrium, indicating a transition towards pluripotency.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This in vivo rat study induced endometriosis by autologous transplantation of one uterine horn to the mesentery of intestine in 20 albino female rats, with 20 sham-operated controls; ectopic, eutopic, and control endometria were collected at 4 weeks and analyzed using quantitative RT-PCR and immunohistochemistry for Thy1 (CD90), SSEA1 (FUT4), and Oct4. The authors found that ectopic endometrium expressed significantly higher Oct4 and SSEA1 mRNA than control endometrium, while mRNA levels were comparable between ectopic and eutopic tissues and between eutopic and control; Oct4 immunoscores were higher in ectopic than both eutopic and control endometrium (P=0.02), whereas Thy1 and SSEA1 immunoscores were similar across groups. A key caveat is that the study measures gene/protein expression at a single 4-week time point, limiting conclusions about temporal dynamics and functional stem-cell transitions. This paper is centrally about endometriosis — it uses a rat endometriosis model to assess stemness/pluripotency marker changes (Oct4, SSEA1, Thy1) in ectopic versus eutopic endometrium.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cell Differentiation Endometriosis Fucosyltransferases Pluripotent Stem Cells Pluripotent Stem Cells Animals Disease Models, Animal Ectopic Gene Expression Endometriosis Endometriosis Endometriosis Female Fibroblasts Fibroblasts Fibroblasts Fucosyltransferases Gene Expression Genes, Homeobox Octamer Transcription Factor-3 Octamer Transcription Factor-3

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