On-label and off-label drug use in the treatment of endometriosis

Alexander M Quaas, Alexander Quaas, Elizabeth A. Weedin, Weedin EA, Hansen KR, Karl R. Hansen
Fertility and sterility · 2015 · vol. 103(3) , pp. 612–625 · doi:10.1016/j.fertnstert.2015.01.006 · PMID:25637479 · W2013161515
review OA: bronze CC0 ⤵ 32 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This paper reviews the on-label and off-label prescription drug treatments currently used for endometriosis.

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Abstract

Endometriosis, characterized by the presence of endometrial glands and stroma in extrauterine locations, is a significant cause of pelvic pain and infertility, as well as a major health care burden. Although Food and Drug Administration (FDA)-approved treatments are available, the use of "off-label" medications for endometriosis is widespread. In this review, we provide an overview of the current FDA-approved treatments, followed by a detailed review of the major "off-label" treatments being used in the United States and worldwide, including efficacy, side effects, drug interactions, contraindications, and anomaly risks.

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Condition tags

endometriosis

MeSH descriptors

Drug Labeling Drug Prescriptions Endometriosis Off-Label Use Contraceptives, Oral, Hormonal Contraceptives, Oral, Hormonal Endometriosis Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Ovulation Inhibition Ovulation Inhibition Progestins Progestins United States United States Food and Drug Administration

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (32)

Source provenance

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License: CC0 · commercial use OK