Hormonal therapy for endometriosis: from molecular research to bedside

Claudia Tosti; Antonella Biscione; Giuseppe Morgante; Giuseppe Bifulco; Stefano Luisi; Felice Petraglia

doi:10.1016/j.ejogrb.2016.05.032

Hormonal therapy for endometriosis: from molecular research to bedside

Claudia Tosti, Antonella Biscione, Giuseppe Morgante, Giuseppe Bifulco, Stefano Luisi, Felice Petraglia

European journal of obstetrics, gynecology, and reproductive biology · 2016 · vol. 209 , pp. 61–66 · doi:10.1016/j.ejogrb.2016.05.032 · PMID:27503693 · W2399797665

review OA: green CC0 ⤵ 75 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review covers hormonal therapy for endometriosis, exploring its molecular mechanisms and clinical applications for patient treatment.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Aromatase Inhibitors Endometriosis Hormone Antagonists Levonorgestrel Medroxyprogesterone Acetate Selective Estrogen Receptor Modulators Aromatase Inhibitors Endometriosis Female Hormone Antagonists Humans Levonorgestrel Medroxyprogesterone Acetate Selective Estrogen Receptor Modulators Treatment Outcome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (98)

A 3-year follow-up of women with endometriosis and pelvic pain users of the levonorgestrel-releasing intrauterine system via openalex
A danazol-loaded intrauterine device decreases dysmenorrhea, pelvic pain, and dyspareunia associated with endometriosis via openalex
A dose‐ranging study to determine the efficacy and safety of 1, 2, and 4 mg of dienogest daily for endometriosis via openalex
Alexithymia in Women with Deep Endometriosis? A Pilot Study via openalex
A novel mifepristone-loaded implant for long-term treatment of endometriosis: In vitro and in vivo studies via openalex
Antiproliferative effects of anastrozole, methotrexate, and 5-fluorouracil on endometriosis in vitro and in vivo via openalex
An update on the pharmacological management of endometriosis via openalex
Changes in quality of life after hormonal treatment of endometriosis via openalex
Changes in quality of life after hormonal treatment of endometriosis via openalex
Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study via openalex
Comparison of aromatase inhibitor (letrozole) and immunomodulators (infliximab and etanercept) on the regression of endometriotic implants in a rat model via openalex
Danazol for pelvic pain associated with endometriosis via openalex
Depot medroxyprogesterone acetate versus an oral contraceptive combined with very-low-dose danazol for long-term treatment of pelvic pain associated with endometriosis via openalex
Dienogest: A New Therapeutic Agent for the Treatment of Endometriosis via openalex
Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis via openalex
Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex
Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial via openalex
Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study via openalex
Dienogest Treatment Improves Quality of Life in Women with Endometriosis via openalex
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis via openalex
Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis via openalex
Effect of norethindrone acetate in the treatment of symptomatic endometriosis. via openalex
Effects of aromatase inhibitors on proliferation and apoptosis in eutopic endometrial cell cultures from patients with endometriosis via openalex
Effects of the levonorgestrel-releasing intrauterine system on cell proliferation, Fas expression and steroid receptors in endometriosis lesions and normal endometrium via openalex
Efficacy of the levonorgestrel-releasing intrauterine device in the treatment of recurrent pelvic pain in multitreated endometriosis. via openalex
Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age via openalex
Efficacy of vaginal danazol treatment in women with recurrent deeply infiltrating endometriosis via openalex
Elagolix Treatment for Endometriosis-Associated Pain: Results from a Phase 2, Randomized, Double-Blind, Placebo-Controlled Study via openalex
Endometriosis via openalex
Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis via openalex
Endometriosis: the effects of dienogest via openalex
Endometriosis: the effects of dienogest. via openalex
Gonadotropin-releasing hormone agonist and add-back therapy: what do the data show? via openalex
Gonadotropin releasing hormone agonists: Expanding vistas via openalex
Hormonal Add-Back Therapy for Females Treated With Gonadotropin-Releasing Hormone Agonist for Endometriosis via openalex
Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial via openalex
Multiple Beneficial Roles of Repressor of Estrogen Receptor Activity (REA) in Suppressing the Progression of Endometriosis via openalex
New trends for the medical treatment of endometriosis via openalex
New trends of progestins treatment of endometriosis via openalex
Norethisterone acetate in the treatment of colorectal endometriosis: a pilot study via openalex
Novel conservative medical therapy for uterine adenomyosis with a danazol-loaded intrauterine device via openalex
Novel vaginal danazol ring therapy for pelvic endometriosis, in particular deeply infiltrating endometriosis via openalex
On-label and off-label drug use in the treatment of endometriosis via openalex
Pathogenesis and pathophysiology of endometriosis via openalex
Pathogenetic Mechanisms of Deep Infiltrating Endometriosis via openalex
Pharmacodynamic study of four oral dosages of dienogest via openalex
Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis via openalex
Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis via openalex
Progesterone receptor modulators in gynaecological practice via openalex
Progestins for the Treatment of Endometriosis: An Update via openalex
Progestins for the Treatment of Endometriosis: An Update: via openalex
Progestogens for endometriosis: forward to the past via openalex
Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis1 via openalex
Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment via openalex
Return of Chronic Pelvic Pain From Endometriosis After Raloxifene Treatment via openalex
Role of the vaginally administered aromatase inhibitor anastrozole in women with rectovaginal endometriosis: a pilot study via openalex
Selective progesterone receptor modulators in reproductive medicine: pharmacology, clinical efficacy and safety via openalex
Sexual Function in Women with Deep Endometriosis: Correlation with Quality of Life, Intensity of Pain, Depression, Anxiety, and Body Image via openalex
Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain via openalex
Subcutaneous injection of depot medroxyprogesterone acetate compared with leuprolide acetate in the treatment of endometriosis-associated pain via openalex
Successful treatment of refractory endometriosis-related chronic pelvic pain with aromatase inhibitors in premenopausal patients via openalex
Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist Elagolix via openalex
The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis via openalex
The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model via openalex
The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial via openalex
The efficacy, side-effects and continuation rates in women with symptomatic endometriosis undergoing treatment with an intra-uterine administered progestogen (levonorgestrel): a 3 year follow-up via openalex
The evaluation of the effectiveness of an intrauterine-administered progestogen (levonorgestrel) in the symptomatic treatment of endometriosis and in the staging of the disease via openalex
The levonorgestrel-releasing intrauterine device reduces CA-125 serum levels in patients with endometriosis via openalex
Treatment of endometriosis with the novel selective progesterone receptor modulator (SPRM) asoprisnil via openalex
Treatment of pain associated with deep endometriosis: alternatives and evidence via openalex
Treatment of severe recurrent endometriosis with an aromatase inhibitor in a young ovariectomised woman via openalex
Treatment of symptomatic rectovaginal endometriosis with an estrogen–progestogen combination versus low-dose norethindrone acetate via openalex
Treatment with Bazedoxifene, a Selective Estrogen Receptor Modulator, Causes Regression of Endometriosis in a Mouse Model via openalex
Use of GnRH antagonists in the treatment of endometriosis via openalex
Validation of Rat Endometriosis Model by Using Raloxifene as a Positive Control for the Evaluation of Novel SERM Compounds via openalex
W1984938820 via openalex
W1910306760 via openalex
W6631333211 via openalex
W6658221620 via openalex
W6668919717 via openalex
W6680384249 via openalex
W6696811538 via openalex
W6698553463 via openalex
W2128175762 via openalex
W99140794 via openalex
W2131027406 via openalex
W2123134517 via openalex
W2021687464 via openalex
W2005761498 via openalex
W2101417341 via openalex
W2157853773 via openalex
W2095424038 via openalex
W2093512443 via openalex
W2045458073 via openalex
W2046911682 via openalex
W2067202752 via openalex
W2082368668 via openalex
W2053998452 via openalex

Cited by (50)

Source provenance

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License: CC0 · commercial use OK

[1] A 3-year follow-up of women with endometriosis and pelvic pain users of the levonorgestrel-releasing intrauterine system via openalex

[2] A danazol-loaded intrauterine device decreases dysmenorrhea, pelvic pain, and dyspareunia associated with endometriosis via openalex

[3] A dose‐ranging study to determine the efficacy and safety of 1, 2, and 4 mg of dienogest daily for endometriosis via openalex

[4] Alexithymia in Women with Deep Endometriosis? A Pilot Study via openalex

[5] A novel mifepristone-loaded implant for long-term treatment of endometriosis: In vitro and in vivo studies via openalex

[6] Antiproliferative effects of anastrozole, methotrexate, and 5-fluorouracil on endometriosis in vitro and in vivo via openalex

[7] An update on the pharmacological management of endometriosis via openalex

[8] Changes in quality of life after hormonal treatment of endometriosis via openalex

[9] Changes in quality of life after hormonal treatment of endometriosis via openalex

[10] Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study via openalex

[11] Comparison of aromatase inhibitor (letrozole) and immunomodulators (infliximab and etanercept) on the regression of endometriotic implants in a rat model via openalex

[12] Danazol for pelvic pain associated with endometriosis via openalex

[13] Depot medroxyprogesterone acetate versus an oral contraceptive combined with very-low-dose danazol for long-term treatment of pelvic pain associated with endometriosis via openalex

[14] Dienogest: A New Therapeutic Agent for the Treatment of Endometriosis via openalex

[15] Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis via openalex

[16] Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex

[17] Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial via openalex

[18] Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study via openalex

[19] Dienogest Treatment Improves Quality of Life in Women with Endometriosis via openalex

[20] Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis via openalex

[21] Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis via openalex

[22] Effect of norethindrone acetate in the treatment of symptomatic endometriosis. via openalex

[23] Effects of aromatase inhibitors on proliferation and apoptosis in eutopic endometrial cell cultures from patients with endometriosis via openalex

[24] Effects of the levonorgestrel-releasing intrauterine system on cell proliferation, Fas expression and steroid receptors in endometriosis lesions and normal endometrium via openalex

[25] Efficacy of the levonorgestrel-releasing intrauterine device in the treatment of recurrent pelvic pain in multitreated endometriosis. via openalex

[26] Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age via openalex

[27] Efficacy of vaginal danazol treatment in women with recurrent deeply infiltrating endometriosis via openalex

[28] Elagolix Treatment for Endometriosis-Associated Pain: Results from a Phase 2, Randomized, Double-Blind, Placebo-Controlled Study via openalex

[29] Endometriosis via openalex

[30] Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis via openalex

[31] Endometriosis: the effects of dienogest via openalex

[32] Endometriosis: the effects of dienogest. via openalex

[33] Gonadotropin-releasing hormone agonist and add-back therapy: what do the data show? via openalex

[34] Gonadotropin releasing hormone agonists: Expanding vistas via openalex

[35] Hormonal Add-Back Therapy for Females Treated With Gonadotropin-Releasing Hormone Agonist for Endometriosis via openalex

[36] Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial via openalex

[37] Multiple Beneficial Roles of Repressor of Estrogen Receptor Activity (REA) in Suppressing the Progression of Endometriosis via openalex

[38] New trends for the medical treatment of endometriosis via openalex

[39] New trends of progestins treatment of endometriosis via openalex

[40] Norethisterone acetate in the treatment of colorectal endometriosis: a pilot study via openalex

[41] Novel conservative medical therapy for uterine adenomyosis with a danazol-loaded intrauterine device via openalex

[42] Novel vaginal danazol ring therapy for pelvic endometriosis, in particular deeply infiltrating endometriosis via openalex

[43] On-label and off-label drug use in the treatment of endometriosis via openalex

[44] Pathogenesis and pathophysiology of endometriosis via openalex

[45] Pathogenetic Mechanisms of Deep Infiltrating Endometriosis via openalex

[46] Pharmacodynamic study of four oral dosages of dienogest via openalex

[47] Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis via openalex

[48] Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis via openalex

[49] Progesterone receptor modulators in gynaecological practice via openalex

[50] Progestins for the Treatment of Endometriosis: An Update via openalex

[51] Progestins for the Treatment of Endometriosis: An Update: via openalex

[52] Progestogens for endometriosis: forward to the past via openalex

[53] Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis1 via openalex

[54] Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment via openalex

[55] Return of Chronic Pelvic Pain From Endometriosis After Raloxifene Treatment via openalex

[56] Role of the vaginally administered aromatase inhibitor anastrozole in women with rectovaginal endometriosis: a pilot study via openalex

[57] Selective progesterone receptor modulators in reproductive medicine: pharmacology, clinical efficacy and safety via openalex

[58] Sexual Function in Women with Deep Endometriosis: Correlation with Quality of Life, Intensity of Pain, Depression, Anxiety, and Body Image via openalex

[59] Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain via openalex

[60] Subcutaneous injection of depot medroxyprogesterone acetate compared with leuprolide acetate in the treatment of endometriosis-associated pain via openalex

[61] Successful treatment of refractory endometriosis-related chronic pelvic pain with aromatase inhibitors in premenopausal patients via openalex

[62] Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist Elagolix via openalex

[63] The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis via openalex

[64] The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model via openalex

[65] The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial via openalex

[66] The efficacy, side-effects and continuation rates in women with symptomatic endometriosis undergoing treatment with an intra-uterine administered progestogen (levonorgestrel): a 3 year follow-up via openalex

[67] The evaluation of the effectiveness of an intrauterine-administered progestogen (levonorgestrel) in the symptomatic treatment of endometriosis and in the staging of the disease via openalex

[68] The levonorgestrel-releasing intrauterine device reduces CA-125 serum levels in patients with endometriosis via openalex

[69] Treatment of endometriosis with the novel selective progesterone receptor modulator (SPRM) asoprisnil via openalex

[70] Treatment of pain associated with deep endometriosis: alternatives and evidence via openalex

[71] Treatment of severe recurrent endometriosis with an aromatase inhibitor in a young ovariectomised woman via openalex

[72] Treatment of symptomatic rectovaginal endometriosis with an estrogen–progestogen combination versus low-dose norethindrone acetate via openalex

[73] Treatment with Bazedoxifene, a Selective Estrogen Receptor Modulator, Causes Regression of Endometriosis in a Mouse Model via openalex

[74] Use of GnRH antagonists in the treatment of endometriosis via openalex

[75] Validation of Rat Endometriosis Model by Using Raloxifene as a Positive Control for the Evaluation of Novel SERM Compounds via openalex

[76] W1984938820 via openalex

[77] W1910306760 via openalex

[78] W6631333211 via openalex

[79] W6658221620 via openalex

[80] W6668919717 via openalex

[81] W6680384249 via openalex

[82] W6696811538 via openalex

[83] W6698553463 via openalex

[84] W2128175762 via openalex

[85] W99140794 via openalex

[86] W2131027406 via openalex

[87] W2123134517 via openalex

[88] W2021687464 via openalex

[89] W2005761498 via openalex

[90] W2101417341 via openalex

[91] W2157853773 via openalex

[92] W2095424038 via openalex

[93] W2093512443 via openalex

[94] W2045458073 via openalex

[95] W2046911682 via openalex

[96] W2067202752 via openalex

[97] W2082368668 via openalex

[98] W2053998452 via openalex