[Expressions of nuclear factor-kappaB and intercellular adhesion molecule-1 in endometriosis].
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Abstract
OBJECTIVE: To investigate the association of nuclear factor-kappaB (NF-kappaB) and intercellular adhesion molecule-1 (ICAM-1) with endometriosis. METHODS: Immunohistochemistry was used to examine the NF-kappaB and VEGF protein expression in 35 specimens of normal endometrium, 48 eutopic endometrium of endometriosis and 76 ectopic endometrium, and the results were analyzed statistically. RESULTS: The expressions of NF-kappaB and ICAM-1 were found mainly in the glandular epithelial cells of the three endometrium specimens, with the ectopic endometriotic tissues showing the highest and normal endometrium the lowest expressions (P<0.001). NF-kappaB and ICAM-1 expressions were positively correlated to normal, eutopic and ectopic endometrium (r=0.688, 0.773 and 0.777, respectively, P<0.01). CONCLUSION: NF-kappaB and ICAM-1 may participate in the process of the pathogenesis in endometriosis.
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Cited by (10)
- Expression of NF-κB, Bcl-2 and Caspase-8 apoptosis markers in endometrium in external genital endometriosis and chronic endometritis: A retrospective study 2023
- Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture 2018
- The Usefulness of CD34, PCNA Immunoreactivity, and Histopathological Findings for Prediction of Pain Persistence After the Removal of Endometrioma 2018
- The Expression of Cyclophilin A in Ovarian Endometrioma: Its Correlation with Recurrence and Vascularity 2017
- Endometrial biomarkers for the non-invasive diagnosis of endometriosis 2016
- Atorvastatin exerts anti-nociceptive activity and decreases serum levels of high-sensitivity C-reactive protein and tumor necrosis factor-α in a rat endometriosis model 2014
- Remission of Endometriosis by Hyperbaric Oxygen Treatment in Rats 2011
- Pelvic Mechanisms Involved in the Pathophysiology of Pain in Endometriosis 2011
- Combating endometriosis by blocking proteasome and nuclear factor- B pathways 2008
- Dioxin may promote inflammation-related development of endometriosis 2008
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