Peritoneal endometriosis induces time-related depressive- and anxiety-like alterations in female rats: involvement of hippocampal pro-oxidative and BDNF alterations

Paulo Wagner Linhares Lima Filho, Adriano José Maia Chaves Filho, Charliene Freire Xavier Vieira, Tatiana de Queiroz Oliveira, Michelle Verde Ramo Soares, Paloma Marinho Jucá, João Quevedo, Joao Quevedo, Tatiana Barichello, Danielle S. Macêdo, Francisco das Chagas Medeiros
Metabolic brain disease · 2019 · vol. 34(3) , pp. 909–925 · doi:10.1007/s11011-019-00397-1 · PMID:30798429 · W2916191916
article OA: closed CC0 ⤵ 11 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Peritoneal endometriosis in rats progressively increased anxiety-like and despair-like behaviors, accompanied by pain sensitivity, oxidative stress, and reduced hippocampal BDNF.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper examined time-related behavioral and biological changes in female rats using a peritoneal endometriosis model created by weekly peritoneal auto-transplantation of uterine tissue for three weeks, assessing anxiety-like, despair-like, and depressive-like behaviors alongside corticosterone stress reactivity, oxidative stress markers (GSH, lipid peroxidation, SOD, MPO), and hippocampal BDNF levels. Progressive anxiety-like behavior increased from days 14–21 post-EM, with despair-like behavior appearing by day 14 and anhedonia/apathetic-like behaviors plus increased corticosterone response observed at day 21. Oxidative changes showed a time course, with decreased GSH and increased SOD at day 21 and lipid peroxidation altered from day 14, while BDNF decreased at day 21. The study’s caveat is that it uses an animal model and evaluates a limited set of hippocampal oxidative/neurotrophic endpoints to infer mechanisms. This paper is centrally about endometriosis—specifically, it uses an experimental endometriosis model to link peritoneal endometriosis–induced, time-dependent depressive/anxiety-like behaviors with hippocampal pro-oxidative and BDNF alterations.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Behavior, Animal Brain-Derived Neurotrophic Factor Endometriosis Hippocampus Animals Antidepressive Agents Antidepressive Agents Antioxidants Antioxidants Anxiety Disorders Anxiety Disorders Anxiety Disorders Behavior, Animal Brain-Derived Neurotrophic Factor Brain-Derived Neurotrophic Factor Depression Depression Depression Depressive Disorder Depressive Disorder

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