Follicular fluid lipid peroxidation levels in women with endometriosis during controlled ovarian hyperstimulation

de Lima CB, Camila Bruna de Lima, Fernanda Bertuccez Cordeiro, Mariana Camargo, Daniel Suslik Zylbersztejn, Cedenho AP, Agnaldo Pereira Cedenho, A.P. Cedenho, Ricardo Pimenta Bertolla, Lo Turco EG, E.G. Lo Turco, Edson Guimarães Lo Turco
Human fertility (Cambridge, England) · 2016 · vol. 20(1) , pp. 48–54 · doi:10.1080/14647273.2016.1246753 · PMID:27802789 · W2547795906
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This study found that women with endometriosis undergoing controlled ovarian hyperstimulation had higher follicular fluid lipid peroxidation levels, and that pregnancy likelihood decreased with age in these patients.

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Abstract

This observational study aimed to establishing a relationship between lipid peroxidation and endometriosis in women undergoing controlled ovarian hyperstimulation. A total of 79 women were divided into two groups: (i) controls (tubal or male factor); and (ii) endometriosis (stages III/IV). The endometriosis diagnosis was confirmed by videolaparoscopy and the controlled ovarian stimulation protocol was similar to all patients. Follicular fluid (FF) lipid peroxidation levels were determined through the quantification of malondialdehyde. Statistical analysis was performed using parametric and non-parametric tests, logistic regression was performed to estimate the chance of achieving a pregnancy in each group and a moving average was calculated for the endometriosis group. Peroxidation levels in the endometriosis group were significantly higher when compared to controls. The moving average showed a decrease of MDA levels in the endometriosis group with increasing female age. Moreover, women with endometriosis who were under 33 years of age were 4.3 times more likely to achieve a pregnancy than women above that age. In conclusion, endometriosis is associated with increased FF oxidative stress (OS) in patients undergoing in vitro fertilization (IVF). Also, increasing age is associated with a decrease in severity of the oxidative status, but a decreased chance of pregnancy.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fertility Agents, Female Follicular Fluid Lipid Peroxidation Ovulation Induction Adult Aging Chorionic Gonadotropin Chorionic Gonadotropin Embryo Transfer Endometriosis Female Fertility Agents, Female Follicle Stimulating Hormone Follicle Stimulating Hormone Follicular Fluid Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Hormones

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