Endometriosis and assisted reproductive technologies: are outcomes affected?
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While endometriosis may not affect overall IVF pregnancy rates, it can impair oocyte quality and implantation, suggesting optimized ART protocols might improve outcomes.
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Abstract
The preponderance of recent data suggests that endometriosis does not adversely affect in-vitro fertilization pregnancy rates. However, many studies demonstrate impaired oocyte quality, decreased fertilization, and compromised implantation rates. Such findings give insight into the mechanisms by which endometriosis may impact on fertility, and provide clues as how to focus assisted reproductive technologies in order to overcome these deficiencies. Specifically, extended downregulation protocols, ample use of gonadotropins for ovarian stimulation, and conservative management of endometriomas have all been suggested as means to optimize in-vitro fertilization outcomes for women with endometriosis.
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Cited by (27)
- Topic- impact of laparoscopic cystectomy and endometrioma size on IVF outcomes: insights from a retrospective cohort study 2025
- The rate of oocytes with granular cytoplasm is higher in women with endometrioma in ICSI cycles 2021
- Laparoscopic surgery 2019
- Follicular fluid lipid peroxidation levels in women with endometriosis during controlled ovarian hyperstimulation 2016
- Oocyte quality is decreased in women with minimal or mild endometriosis 2015
- Effect of endometriosis on implantation rates when compared to tubal factor in fresh non donor in vitro fertilization cycles 2014
- Utero-ovarian hemodynamics after laparoscopic treatment of infertility caused by moderate to severe endometriosis 2013
- Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis 2012
- Cellular and molecular basis for endometriosis-associated infertility 2012
- Evidence-based long-term management of endometriosis: Medical therapy and treatment of infertility 2011
- Implantation Rate Remains Unaffected in Women with Endometriosis Compared to Tubal Factor Infertility 2011
- Assessment of Oocyte and Embryo Quality in Women with Endometriosis 2010
- Assessment of oocyte and embryo quality in women with endometriosis 2010
- THE OUTCOME OF IN VITRO FERTILIZATION / INTRACYTOPLASMIC SPERM INJECTION IN ENDOMETRIOSIS–ASSOCIATED AND TUBAL FACTOR INFERTILITY 2009
- Epidemiological factors influencing IVF outcome: Evidence from the Yale IVF program 2008
- ALPHA V BETA 3 INTEGRIN EXPRESSION IN THE ENDOMETRIUM OF INFERTILE WOMEN WITH ENDOMETRIOSIS 2008
- Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility 2007
- Endometriosis and Adenomyosis 2007
- Long-term use of gonadotropin-releasing hormone analogues before IVF in women with endometriosis 2007
- TENASCIN-C EXPRESSION IN ENDOMETRIOSIS 2005
- Is laparoscopy necessary before assisted reproductive technology? 2005
- Endometriose und Infertilität 2005
- Role of laparoscopic treatment of endometriosis in patients with failed in vitro fertilization cycles 2005
- Removal of endometriomas before in vitro fertilization does not improve fertility outcomes: a matched, case–control study 2004
- The Role of Cytokines in Endometriosis* 2003
- Endometrial Pinopode and αvβ3 Integrin Expression Is Not Impaired in Infertile Patients with Endometriosis 2003
- Ovarian endometriosis and peritoneal endometriosis: are they different entities from a fertility perspective? 2002
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