Utero-ovarian hemodynamics after laparoscopic treatment of infertility caused by moderate to severe endometriosis
This study investigated utero-ovarian hemodynamic parameters, measured by resistance indices, following laparoscopic treatment for infertility due to moderate to severe endometriosis.
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This doctoral dissertation evaluated utero-ovarian hemodynamic parameters (pulsatility and resistance indexes measured by ultrasonographic color Doppler of uterine and ovarian arteries) in 60 infertile women with moderate (35) or severe (25) endometriosis and 45 infertile controls without endometriosis, using CA-125 as a supplementary diagnostic marker. The study found that CA-125 concentrations >60 U/mL were more frequent in moderate-to-severe disease, lesion localization (including rectovaginal locations in severe cases) was associated with altered uterine/ovarian arterial flow indices, and both pulsatility and resistance indexes were generally higher than in healthy women, with resistance particularly elevated in severe endometriosis. After laparoscopic treatment aimed at removing lesions, ovarian-artery hemodynamic parameters improved by 3–6 months in both stages, uterine-artery improvement was more limited (only resistance index decreased), and pregnancies occurred in 11.4% (moderate) and 4% (severe) of cases, with significant recovery of all measured hemodynamic parameters only in the subgroup achieving pregnancy, though follow-up appears limited to that short postoperative interval. This paper is centrally about endometriosis—specifically the effect of laparoscopic treatment on utero-ovarian hemodynamics in infertile women with moderate to severe endometriosis.
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