ALPHA V BETA 3 INTEGRIN EXPRESSION IN THE ENDOMETRIUM OF INFERTILE WOMEN WITH ENDOMETRIOSIS

Amal Azzam, Amal Z. Azzam, A. Nahla, Nahla A.
The Egyptian Journal of Fertility of Sterility · 2008 · vol. 12(2) , pp. 51–64 · doi:10.21608/egyfs.2008.4865 · W2782444763
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Alpha v beta 3 integrin expression is reduced during the implantation window in infertile women with early-stage endometriosis compared to fertile controls.

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Abstract

Objectives : To evaluate the expression of Alpha V Beta 3 inlegrin (ccVpo) in infertile women with endometriosis in themidluteal in-phase endometrial biopsies.Design: Prospective controlled study.Setting: Department of Obstetrics and Gynaecology, Shatby University Hospital and Department of Pathology.Alexandria University.Subjects: Twenty five infertile females having stage I or II endometriosis (group I) and twenty fertile controls (groupII).Interventions: Midluteal endometrial biopsies by suction pipette were earned out during the implantation window.Immunohistochemical staining for the expression of aVP3 integrins and progesterone receptors (PR) in endometrialsamples were performed. Serum levels of estradiol and progesterone were measured at the same day of endometrialbiopsy.Main outcome measures: aVf33 inlegrin was significantly reduced (p=0.001) in infertile patients with endometriosis(44%) compared to fertile controls (80%). Patients in group (I) had a statistically significant reduction (p=0.001) in theoverall mean intensity score compared to women in group (II) (0.52+0.65vs 2.011.21). The expression of ocV[j3 wasmainly glandular in both groups. However, in patients with positive inlegrin expression, the percentage of glandularexpression as well as the mean intensity score was significantly reduced in group (I) compared to group (II) (p=0.001,p=0.0001 respectively). Hormonal levels were comparable between groups. The epithelial PRs were down regulated inall in-phase endometrial samples in both groups. Integrin expression was inversely correlated with epithelial PRs in thecontrol group (r= - 0.89, p=0.001) but no correlation was found in the endometriosis group (r=0.14, p = 0.39).Conclusion: aV|33 integrin expression is reduced during the window of implantation in infertile patients with stage I orII endometriosis denoting that defective uterine receptivity might be an unrecognized cause of associdated infertility inthose women,

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endometriosisinfertility

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